Download PDF by Kendra L. Cann, Sui Huang, Graham Dellaire (auth.), Niall M.: Advances in Nuclear Architecture

By Kendra L. Cann, Sui Huang, Graham Dellaire (auth.), Niall M. Adams, Paul S. Freemont (eds.)

ISBN-10: 9048198984

ISBN-13: 9789048198986

ISBN-10: 9048198992

ISBN-13: 9789048198993

This ebook presents a image of the state-of-the artwork within the research of mammalian cellphone nuclear structure, and lines a various variety of chapters written by means of best researchers. A key point is an emphasis on particular and repeatable quantitative research and simulation as well as the extra time-honored organic standpoint. The fusion of such fabric frames the way forward for the self-discipline. Quantitative contributions rigidity reproducible and strong 3D research, utilizing numerous instruments starting from aspect trend research to form registration equipment. organic insights comprise the function of nuclear subdomains in melanoma, nuclear molecular vehicles, and a holistic view of gene transcription.

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2001; Gonzalez et al. 2006; Zhu et al. 2009). The PML protein is the main component of nuclear structures known as PML nuclear bodies (Dyck et al. 1994; Koken et al. 1994). 2 and [Dellaire and Bazett-Jones 2004; Bernardi and Pandolfi 2007]). Following treatment with doxorubicin (a DNA intercalator and topoisomerase II inhibitor), PML can sequester MDM2 in the nucleolus via an interaction with the ribosomal protein L11, which results in the stabilization of p53 (Bernardi et al. 2004). 6 The Nucleolus and Genome Maintenance As discussed above, the nucleolar protein NPM functions in genome maintenance through its regulation of centrosome duplication (Gjerset 2006).

Bernardi et al. 2008). They function within these pathways by sequestering and/or facilitating the post-translational modification or degradation of genomic caretakers and cell gatekeepers, including the critical tumour suppressor p53 (Dellaire and Bazett-Jones 2004; Dellaire and Bazett-Jones 2007; Bernardi et al. 2008). Furthermore, they physically respond to alterations in cell proliferation, and to cell stress and DNA damage by changing in biochemical composition and number (Dellaire and Bazett-Jones 2004; Dellaire and Bazett-Jones 2007).

It was the first subnuclear structure to be observed, and was first noted over 200 years ago by Fontana (HernandezVerdun 2006a; Raska et al. 2006). However, it was not until the 1960s that it was identified as the location of ribosomal RNA (rRNA) transcription (HernandezVerdun 2006a). As the site of rRNA transcription and ribosome biogenesis, the nucleolus is the canonical example of the relationship between structure and function in the nucleus (Dundr and Misteli 2001; Hernandez-Verdun 2006a).

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Advances in Nuclear Architecture by Kendra L. Cann, Sui Huang, Graham Dellaire (auth.), Niall M. Adams, Paul S. Freemont (eds.)


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