By E. Grote, F. Bonzelius, G. Herman (auth.), K. S. Kosik M.D., D. J. Selkoe M.D., Y. Christen Ph.D. (eds.)
Like the unflinching gaze of Captain Ahab strolling the deck of the Pequod, Alzheimer researchers have had their points of interest fastened firmly at the sickness for a few years. Now, as this quantity amply demonstrates, finished researchers from different fields, who've inspiration deeply approximately phone organic difficulties are making use of their insights to Alzheimer's sickness. The contri butions the following signify the textual content models of the complaints from the 10th "Colloque medecine et recherche" of the Fondation IPSEN dedicated to learn on Alzheimer's ailment. The symposium, entitled "Alzheimer's affliction: classes from mobilephone Biology" used to be held in Paris on April 25, 1994. As is clear from the numerous backgrounds of the members, the clinical pursuit of Alzheimer's affliction has all started to meld with extra uncomplicated disciplines, rather telephone biology. whereas at the one hand, new components of specialization are continually rising, the bounds of older disciplines are increas ingly blurred. possibly for many of the years because the first descriptions of the ailment in 1907, the technological know-how of Alzheimer's ailment used to be descriptive, and lay within the province of pathologists. this period of time, in which greatly used to be discovered in regards to the topography of senile plaques and neurofibrillary tangles, culminated with an ultrastructural description of those hallmark buildings. the fashionable period of Alzheimer's disorder examine opened with the iden tification of the part proteins in plaques and tangles.
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Extra info for Alzheimer’s Disease: Lessons from Cell Biology
Fig. 3. Pathways of sorting and transport in the trans-Golgi network (TGN). (Taken from a figure to be published in Current Opinion in Cell Biology) Mechanisms of Molecular Sorting in Polarized Cells: Relevance to Alzheimer's Disease 21 known to reach the apical surface (Wandinger-Ness and Simons 1990; Zurzolo et al. 1994). Understanding the mechanism of sorting, the nature of the coat proteins that may be involved, and the features that distinguish apical and basolateral transport vesicles represents the major problems for future research.
It is also likely, however, that APP cleavage occurs during transit through biosynthetic organelles (Haass et a1. 1992). Several rare mutations are known that lead to early onset familial Alzheimer's disease (FAD; Fig. 4). In the best-studied case, members of a large Swedish kindred were found to have a mutation in the APP ectodomain near the site of a-secretase cleavage (codons 670/671; lys -') met and asn -') leu). Mutations at this site significantly increased the amount of AfJ released by increasing the amount of fJ-cleavage that occurred (Citron et a1.
Cell 74: 1053-1064 Mellman I, Yamamoto E, Whitney lA, Kim M, Hunziker W, Matter K (1993) Molecular sorting in polarized and non-polarized cells: common problems, common solutions. 1 Cell Sci Suppl17: 1-7 Roberts SB, Ripellino JA, Ingalls KM, Robakis NK, Felsenstein KM (1994) Nonamyloidogenic cleavage of the p-amyloid precursor protein by an integral membrane metalloendopeptidase. J Bioi Chern 269: 3111-3116 Rodriguez-Boulan E, Nelson WJ (1989) Morphogenesis of the polarized epithelial cell phenotype.
Alzheimer’s Disease: Lessons from Cell Biology by E. Grote, F. Bonzelius, G. Herman (auth.), K. S. Kosik M.D., D. J. Selkoe M.D., Y. Christen Ph.D. (eds.)