By Jane Kneller, Sidney Axinn
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Extra info for Autonomy and Community: Readings in Contemporary Kantian Social Philosophy (S U N Y Series in Social and Political Thought)
1978) took special precautions to show the specificity of the PNT activity that is diminished in lymphocytes from the patients described above. The PNT activity was uninfluenced by various concentrations of inhibitors of alkaline and acid phosphatase, including cysteine, DISORDERS OF PURINE AND PYRIMIDINE METABOLISM 29 ,B-glycerophosphate, and sodium potassium tartrate. None of these agents produced any significant inhibition. In contrast, the more specific 5'nucleotidase inhibitor TTP produced 84% inhibition, while ATP produced 94% inhibition.
The ADA-deficient liver showed essentially a normal pattern of distribution of residual enzyme activity between the two high-molecular-weight forms (580,000-260,000 daltons). , 1978). The residual activity from the spleen of a child who died at age 2112 years with ADA deficiency and severe combined immunodeficiency disease was studied in detail by Schrader et at. (1978). , 1976). They found small amounts of the 12 J. EDWIN SEEGMILLER same activity in normal spleen from which ADA had been removed by absorption on specific antibody.
EDWIN SEEGMILLER lymphocytes at concentrations that either inhibited or had no effect on normal lymphocytes. The possibility that this effect was mediated by activation of the lymphocyte adenosine receptors was proposed by A. L. Schwartz et at. (1979). Turpin et at. (1977) confirmed in fat cells in situ the earlier work of Fain and Wieser (1975) in demonstrating a role for adenosine in modulating hormone-stimulated lipolysis in isolated rate epididymal fat cells. 4. , 1977) focused attention on the importance of the deoxynucleoside degradation pathway (Snyder and Henderson, 1973).
Autonomy and Community: Readings in Contemporary Kantian Social Philosophy (S U N Y Series in Social and Political Thought) by Jane Kneller, Sidney Axinn