Download e-book for iPad: Bacterial Adhesion: Chemistry, Biology and Physics by Jack C. Leo, Mikael Skurnik (auth.), Dirk Linke, Adrian

By Jack C. Leo, Mikael Skurnik (auth.), Dirk Linke, Adrian Goldman (eds.)

ISBN-10: 9400709390

ISBN-13: 9789400709393

Adhesion performs an important position within the bacterial way of life. micro organism can adhere to natural and inorganic surfaces, to one another, and naturally to host cells in the course of pathogenesis.

The concentration of this e-book is: how are such adhesion phenomena most sensible studied? Microbial genetics experiments have enormously more desirable our wisdom of what bacterial elements are considering adhesion. for various purposes, even though, biochemical and structural biology wisdom of the molecular interactions interested by adhesion are restricted. One serious problem has been an absence of interdisciplinary study and knowing within the box. at the one hand, the microbiologists lack targeted wisdom of the biophysical probabilities and feature constrained entry to the often pricey instrumentation concerned whereas nevertheless, the specialists in those equipment usually do not need entry to the organic fabrics, nor do they unavoidably comprehend the organic inquiries to be replied. the aim of this ebook is hence to beat this hole in conversation among researchers in biology, chemistry and physics and to demonstrate the numerous methods and ability to enquire bacterial adhesion. we are hoping to stimulate new and ground-breaking research.

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Additional info for Bacterial Adhesion: Chemistry, Biology and Physics

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Annu Rev Microbiol 61:89–112 Delepelaire P (2004) Type I secretion in gram-negative bacteria. Biochim Biophys Acta 1694: 149–161 Dorsey CW, Laarakker MC, Humphries AD, Weening EH, Bäumler AJ (2005) Salmonella enterica serotype Typhimurium MisL is an intestinal colonization factor that binds fibronectin. Mol Microbiol 57:196–211 Duguid JP (1959) Fimbriae and adhesive properties in Klebsiella strains. J Gen Microbiol 21: 271–286 Gerlach RG, Claudio N, Rohde M, Jäckel D, Wagner C, Hensel M (2008) Cooperation of Salmonella pathogenicity islands 1 and 4 is required to breach epithelial barriers.

Infect Immun 75: 1835–1842 Ahmer BM, van Reeuwijk J, Watson PR, Wallis TS, Heffron F (1999) Salmonella SirA is a global regulator of genes mediating enteropathogenesis. Mol Microbiol 31:971–982 Austin JW, Sanders G, Kay WW, Collinson SK (1998) Thin aggregative fimbriae enhance Salmonella enteritidis biofilm formation. FEMS Microbiol Lett 162:295–301 Bajaj V, Lucas RL, Hwang C, Lee CA (1996) Co-ordinate regulation of Salmonella typhimurium invasion genes by environmental and regulatory factors is mediated by control of hilA expression.

The energy for pilus polymerisation is provided by an assembly ATPase. The assembled pilus is protruded out of the outer membrane through the action of secretin PilQ of N. gonorrhoeae. An additional retraction ATPase mediates the depolymerisation of the pilus leading to a movement called “twitching motility”. This mechanism mediates movement along surfaces as the pilus is retracted while it is still adhered to target surface (Craig and Li, 2008). Besides twitching and gliding motility (Wall and Kaiser, 1999), type IV pili have also been shown to be required for many pathogenic processes including immune escape, DNA uptake, biofilm formation, microcolony formation and adhesion reviewed by (Craig and Li, 2008).

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Bacterial Adhesion: Chemistry, Biology and Physics by Jack C. Leo, Mikael Skurnik (auth.), Dirk Linke, Adrian Goldman (eds.)


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