By Jack C. Leo, Mikael Skurnik (auth.), Dirk Linke, Adrian Goldman (eds.)
Adhesion performs an important position within the bacterial way of life. micro organism can adhere to natural and inorganic surfaces, to one another, and naturally to host cells in the course of pathogenesis.
The concentration of this e-book is: how are such adhesion phenomena most sensible studied? Microbial genetics experiments have enormously more desirable our wisdom of what bacterial elements are considering adhesion. for various purposes, even though, biochemical and structural biology wisdom of the molecular interactions interested by adhesion are restricted. One serious problem has been an absence of interdisciplinary study and knowing within the box. at the one hand, the microbiologists lack targeted wisdom of the biophysical probabilities and feature constrained entry to the often pricey instrumentation concerned whereas nevertheless, the specialists in those equipment usually do not need entry to the organic fabrics, nor do they unavoidably comprehend the organic inquiries to be replied. the aim of this ebook is hence to beat this hole in conversation among researchers in biology, chemistry and physics and to demonstrate the numerous methods and ability to enquire bacterial adhesion. we are hoping to stimulate new and ground-breaking research.
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Additional info for Bacterial Adhesion: Chemistry, Biology and Physics
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The energy for pilus polymerisation is provided by an assembly ATPase. The assembled pilus is protruded out of the outer membrane through the action of secretin PilQ of N. gonorrhoeae. An additional retraction ATPase mediates the depolymerisation of the pilus leading to a movement called “twitching motility”. This mechanism mediates movement along surfaces as the pilus is retracted while it is still adhered to target surface (Craig and Li, 2008). Besides twitching and gliding motility (Wall and Kaiser, 1999), type IV pili have also been shown to be required for many pathogenic processes including immune escape, DNA uptake, biofilm formation, microcolony formation and adhesion reviewed by (Craig and Li, 2008).
Bacterial Adhesion: Chemistry, Biology and Physics by Jack C. Leo, Mikael Skurnik (auth.), Dirk Linke, Adrian Goldman (eds.)