By Mirjana Pavlovic, Bela Balint
This ebook explores the function of melanoma stem cells within the analysis, remedy, and treatment of cancers. This booklet additionally tackles novel technique for melanoma stem cellphone marker id, melanoma stem cellphone breathing and metabolism, genetic and epigenetic mechanisms together with DNA methylation, and mi-RNA gather. It additionally emphasizes the function of Bioinformatics strategies, which offer a unique technique for modeling melanoma outcomes.
The authors examine the variation among melanoma stem cells and general stem cells, besides the concept that of certain melanoma stem cellphone remedy. even though the theoretical reasons of melanoma stem mobile involvement in leukemia and strong cancers are arguable, there's now no doubt that melanoma stem cells exist inside another way heterogeneous melanoma phone inhabitants. The short examines the 2 best theories, hierarchical and the stochastic/cancer stem cellphone model.
Researchers, professors and advanced-level scholars considering bioengineering and machine technology will locate this publication to be a important source. it's a excellent resource of severe references for knowing of this challenge, and a great tool for execs in similar fields.
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Extra resources for Bioengineering and Cancer Stem Cell Concept
Bhartiya D, Kasiviswananthan S, Shaikh A (2012) Cellular origin of testis-derived pluripotent stem cells: a case for very small embryonic-like stem cells. Stem Cells Dev 21(5):670–674 39. Bhartiya D, Shaikh A, Nagvenkar P, Kasiviswanathan S, Pethe P, Pawani H, Mohanty S, Rao SG, Zaveri K, Hinduja I (2012) Very small embryonic-like stem cells with maximum regenerative potential get discarded during cord blood banking and bone marrow processing for autologous stem cell therapy. Stem Cells Dev 21(1):1–6 40.
The progress in reprogramming of iPS cells towards the cardiac lineage/differentiation is going on. The focus is on challenges of cardiac disease modeling using iPS cells and their potential to produce safe, effective and affordable therapies/applications with the emphasis on cardiac tissue engineering. The paper has emphasized implications of human iPS cells to biological research and some of the future needs . Stem cell cancer concept had reached its spike this year . Cancer stem cells (CSCs) share properties similar to those described for tissue stem cells: self-renewal and asymmetric division resulting in the generation of daughter cells destined to differentiate, enabling the regeneration of a tissue.
MNE Medica 1:16–17, ref. p. 43 20. Pavlovic M (2014) Very small embryonic like cells (VSELs): review and perspectives in the light of critical data and controversies. ART 41(1–2):33–47 21. Ratajzcak MZ, Kucia M, Reca R, Majka M et al (2004) Stem cell plasticity revised: CXR4 positive cells expressing mRNA for early muscle, liver and neural cells “hide out” in the bone marrow. Leukemia 19(1):29–40 22. Kucia M, Reca R, Campbell FR, Zuba-Surma E, Majka M, Ratajczak J, Ratajczak MZ (2006) A population of very small embryonic-like (VSEL) CXCR4þSSEA-1þOct-4þ stem cells identified in adult bone marrow.
Bioengineering and Cancer Stem Cell Concept by Mirjana Pavlovic, Bela Balint