By Emil J Freireich M.D., D.Sc. (Hon.) (auth.), Laurence Baker, Frederick Valeriote, Voravit Ratanatharathorn (eds.)
This yr notes significant adjustments within the annual Detroit melanoma Symposium. the 1st is our goal of choosing most sensible ics of wide curiosity to the melanoma group and studying the topic from either a easy laboratory and scientific point of view. during this method, the significance of either components of melanoma study are famous and the interaction among them emphasised. additional, we think that Symposia similar to this act to stimulate the elemental scientist and clinician to proceed their reports with the understand ledge of the influence that every has upon the opposite and the nec essary cooperation required to unravel the melanoma challenge. the second one switch is the booklet of this Symposium. The pre vious 16 weren't dedicated to manuscript shape. Given the swap in structure and reason of the sequence, we think that this and next volumes will make vital contributions to the melanoma literature. the subject of "Biology and remedy of Acute Leukemia" used to be selected for the 1st Symposium as a result of its ancient signif icance in melanoma chemotherapy. The healing motive for human leukemia is the results of knowing the fundamental tumor biology mostly derived from transplantable leukemias in exper imental animals. it really is via those types, as mentioned through Dr. Fred Valeriote, that we realized the mobile kinetics of leukemia, the antileukemic results of latest brokers and the ef fect of progress perturbation by way of a variety of chemotherapeutic brokers and their combinations.
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Extra info for Biology and Therapy of Acute Leukemia: Proceedings of the Seventeenth Annual Detroit Cancer Symposium Detroit, Michigan — April 12–13, 1984
Haematol. 47:553-561, 1981. Savage RA, Hoffman GC, Lucas FV: Morphology and cytochemistry of microgranular acute promyelocytic leukemia (M3m). Am. J. Clin. Pathol. 75:548-552, 1981. Golomb HM, Rowley JD, Vardiman JW, Testa JR, Butler A: nMicrogranular n acute promyelocytic leukemia: A distinct clinical, ultrastructural, and cytogenetic entity. Blood 55:253-259, 1980. Dick FR, Armitage JO, Burns CP: Diagnostic concurrence in the subclassification of adult acute leukemia using FrenchAmerican-British criteria.
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BIOCHEMICAL MODULATION. Each of these concepts are discussed below. Two-drug combinations were first examined in the early days of experimental chemotherapy with the idea of controlling the development of drug resistance following single agent therapy (56), however, it became obvious that positive (synergistic) interactions could occur between agents to increase their effectiveness (57). This led to extensive studies over the years examining nearly every conceivable two-drug combination for interaction as generally defined in terms of increased survival time of leukemia-bearing mice.
Biology and Therapy of Acute Leukemia: Proceedings of the Seventeenth Annual Detroit Cancer Symposium Detroit, Michigan — April 12–13, 1984 by Emil J Freireich M.D., D.Sc. (Hon.) (auth.), Laurence Baker, Frederick Valeriote, Voravit Ratanatharathorn (eds.)