By Sayed S. Daoud
This publication covers present themes on the topic of using proteomic techniques in melanoma treatment in addition to expected demanding situations which could come up from its program in day-by-day perform. It info present applied sciences utilized in proteomics, examines the use proteomics in phone signaling, provides medical purposes of proteomics in melanoma remedy, and appears on the position of the FDA in regulating using proteomics.
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Proteome Res. 5:233–239, 2006. 103. A. J. Proteome Res. 5:240–247, 2006. 104. L. Mol. Cell Proteomics 4:1002–1008, 2005. II Cell Signaling Proteomics 2 Integration of Genomics and Proteomics in Dissecting p53 Signaling Kyunghee Lee, Tao Wang, Abdur Rehman, Yuhua Wang, and Sayed S. Daoud CONTENTS 1 Introduction 2 Genomics of p53 Signaling 3 Proteomics and p53 Target Identiﬁcation 4 Integration of Proteomics in p53 Signaling 5 Conclusions Summary The discovery of the human genome and subsequent expansion of proteomics research combined with emerging technologies such as sophisticated computational biology are producing unprecedented changes in our understanding of the role of tumor suppressors in cell signaling.
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2. GENOMICS OF P53 SIGNALING In the past decade, numerous efforts were made to identify p53 target genes through various gene expression techniques, including microarrays expression analysis and integrative genomic assays. However, these technologies have provided limited coverage for p53 bindings due to the unavailability of the full sequences of the human genome. Following the discovery of the human genome, many novel p53 target genes were identified due to the scientific advancement in genomic methodologies coupled with the availability of many sophisticated molecular database resources.
Cancer Proteomics: From Bench to Bedside (Cancer Drug Discovery and Development) by Sayed S. Daoud