Get Cellular and Molecular Biology of Neuronal Development PDF

By Nicole M. Le Douarin (auth.), Ira B. Black (eds.)

ISBN-10: 1461296862

ISBN-13: 9781461296867

ISBN-10: 1461327172

ISBN-13: 9781461327172

A principal challenge in neurobiology issues mechanisms that generate the professional­ came upon range and specificity of the apprehensive process. what's the substance of diversification and specificity on the molecular, mobile, and platforms degrees? four How, for instance, do 1011 neurons every one shape nearly 10 interconnec­ tions, permitting common physiological functionality? How does disruption of those approaches lead to human affliction? those complaints signify the efforts of molecular biologists, embryologists, neurobiologists, and clinicians to procedure those concerns. during this quantity are grouped by means of topic to offer the kinds The chapters of tools used to method each one person zone. part I offers with embry­ ogenesis and morphogenesis of the apprehensive process. In bankruptcy three, Weston and associates describe using monoclonal antibodies that realize particular neuronal epitopes (including particular gangliosides) for the aim of defining heterogeneity within the neural crest, an enormous version process. Immunocyto­ chemical research finds the life of special sUbpopulations in the crest at tremendous early phases; cells convey neuronal or glial binding styles on the time of migration. for that reason, interactions with the surroundings could decide upon for predetermined populations. Le Douarin reaches related conclusions in bankruptcy 1 via reading migratory pathways and developmental potentials in crest of quail-

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The hypothesis presented above may be tested by determining whether glia plus neurons are derived from these precursor sources. 26 Chapter 1 ACKNOWLEDGMENTS. This work was supported by the Centre National de la Recherche Scientifique, the Delegation Generale it la Recherche Scientifique et Technique (Contrat 80 E 0877), and the NIH (Grant 2 ROl DEO 4257-06). , 1925, The development of the neural folds and cranial ganglia of the rat, J. Camp. Neural. 39: 19-17l. , 1982, The early development of cranial sensory ganglia and the potentialities of their component cells studied in quail-chick chimeras, Dev.

1955, The placodal relations of the neural crest in the domestic cat, J. Anat. 89:133-152. , 1961, Experimental analysis of the dual origin of the trigeminal ganglion in the chick embryo, J. Exp. Zool. 148:91-124. , 1949, Proliferation, differentiation and degeneration in the spinal ganglia of the chick embryo under normal and experimental conditions, J. Exp. Zool. 111:457-502. W. ) Leipzig. B. ), Charles C Thomas, Springfield, Illinois, pp. 76-97. , 1910, The origin of the cranial ganglia in Ameiurus, J.

From Levitt et al. (1981). II CP cc III S· r ~ o ~ ~ ::::J Co m !!!. J 1:3 - Figure 8. Proportion of GFAP-positive and GFAP-negative mitotic figures in the ventricular zone at embryonic (E) days 47,6[, and 80. From Levitt et ai. (1983). generated, almost half the mitotic cells in the subjacent ventricular zone are GFAP-positive (Fig. 8) . At about this embryonic age, few morphologically differentiated astrocytes are visible in the cerebral wall of the rhesus monkey occipital lobe (Schmechel and Rakic, 1979b; Levitt and Rakic, 1980).

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Cellular and Molecular Biology of Neuronal Development by Nicole M. Le Douarin (auth.), Ira B. Black (eds.)


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