By Marco Baggiolini (auth.), Bernhard Moser, Gordon L. Letts, Kuldeep Neote (eds.)
The discovery of interleukin-8 just about twenty years in the past initiated a brand new box of study concerning many elements of immunology and irritation. Interleukin-8 is only one member of a giant category of structurally comparable chemoattractant proteins, referred to as chemokines. Chemokines are focused on the site visitors keep an eye on of leukocytes, which endure the corresponding chemokine receptors on their surfaces. at the present time, it's transparent that chemokines impact all points of immunology or even many unrelated fields, comparable to tissue improvement and tumor telephone metastasis. Their primary contributions to power inflammatory illnesses cause them to a critical objective for the improvement of novel, anti inflammatory therapeutics.
This set of books* supplies a state of the art account of modern advancements during this box within the kind of summaries written by way of very popular specialists. quantity I is concentrated on easy ideas and development in chemokine biology, and quantity II bargains with matters relating to chemokine-related drug improvement and power healing purposes. those volumes offer either introductory and novel details for a vast readership, together with clinicians and biomedical scientists.
*See additionally ok. Neote/G.L. Letts/B. Moser, Chemokine Biology - uncomplicated study and scientific software. quantity II: Pathophysiology of Chemokines. 2006, Birkhäuser, development in irritation study, ISBN 3-7643-7195-1.
Read or Download Chemokine Biology — Basic Research and Clinical Application: Volume I: Immunobiology of Chemokines PDF
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Extra resources for Chemokine Biology — Basic Research and Clinical Application: Volume I: Immunobiology of Chemokines
CCL27 shows 42 Lymphocyte homing to peripheral epithelial tissues a high binding affinity to extracellular matrix proteins and is displayed on cutaneous vascular endothelium, a phenomenon which is explained by the observation that chemokines are transported across endothelium to participate in leukocyte arrest [64, 72, 73]. Moreover, chemokines presented by endothelial cell-associated proteoglycans mediate firm adhesion as well as transendothelial migration. Previous observations suggest that binding to extracellular matrix prolongs the half-live of chemokines and increases their biological activity.
Curr Biol 7: 836–843 Sundrud MS, Grill SM, Ni D, Nagata K, Alkan SS, Subramaniam A, Unutmaz D (2003) Genetic reprogramming of primary human T cells reveals functional plasticity in Th cell differentiation. J Immunol 171: 3542–3549 Jose PJ, Griffiths-Johnson DA, Collins PD, Walsh DT, Moqbel R, Totty NF, Truong O, Hsuan JJ, Williams TJ (1994) Eotaxin: A potent eosinophil chemoattractant cytokine detected in a guinea pig model of allergic airways inflammation. J Exp Med 179: 881–887 Ponath PD, Qin SX, Ringler DJ, Clark-Lewis I, Wang J, Kassam N, Smith H, Shi XJ, Gonzalo JA, Newman W et al (1996) Cloning of the human eosinophil chemoattractant, eotaxin – Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils.
Secretion of IL-4, IL-10 and TGF-β was low to undetectable, arguing against a strict association of CCR8 with either Th2 or regulatory T cell subsets. Importantly, the specific ligand for CCR8, CCL1, is constitutively expressed at strategic cutaneous locations, including dermal microvessels and epidermal antigen presenting cells. In summary, the interaction of CCL1 and CCR8 may contribute to the immune surveillance of the skin in multiple ways . Endothelial cell-derived CCL1 may support the steady-state extravasation of circulating CCR8+ precursors.
Chemokine Biology — Basic Research and Clinical Application: Volume I: Immunobiology of Chemokines by Marco Baggiolini (auth.), Bernhard Moser, Gordon L. Letts, Kuldeep Neote (eds.)