New PDF release: Cholesterol: Its Functions and Metabolism in Biology and

By Simon M. Jackson, Johan Ericsson, Peter A. Edwards (auth.), Robert Bittman (eds.)

ISBN-10: 1461377072

ISBN-13: 9781461377078

ISBN-10: 1461559014

ISBN-13: 9781461559016

Experts examine the biochemical and biomedical facets of ldl cholesterol, addressing its metabolism in basic and affliction states. They speak about a extensive diversity of themes, together with key steps within the ldl cholesterol biosynthetic pathway, and the position of ldl cholesterol in melanoma, atherosclerosis, and illnesses of the worried procedure. The book's finished assurance additionally contains the pathological effects and strength remedies for varied affliction states, and the improvement of latest anti-atherogenic drugs.

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Extra info for Cholesterol: Its Functions and Metabolism in Biology and Medicine

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1995). It is not known whether these latter changes are directly related to apoptosis. Inhibition of HMG-CoA reductase by mevinolin is also reported to result in apoptosis (Perez-Sala and Mollinedo, 1994), even though such treatment inhibits the biosynthesis of famesyl diphosphate, and, presumably, famesol. Thus, the physiological relationship between apoptosis and intracellular isoprenoid alcohol levels remains to be clearly established. 6. ISOPRENOIDS AS TRANSCRIPTIONAL REGULATORS Ecdysone is an insect steroid hormone that controls important regulatory events leading to moulting and metamorphosis.

10. REFERENCES Alberts, A. , 1980, A highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent, Proc. Nati. Acad. Sci. USA 77:3957-3961. Anderson, R. G. , 1993, Caveolae: Where incoming and outgoing messengers meet, Proc. Natl. Acad. Sci. USA 90:10904-10913. , 1995, Retinoid agonist activities of synthetic geranyl geranoic acid derivatives, Biochem. Biophys. Res. Commun. 209:66-72. , 1995, Low density lipoprotein (LDL) cholesterol is converted to 27hydroxycholesterol in human fibroblasts, 1.

1988, Multivalent control of 3-hydroxy-3methylglutaryl coenzyme A reductase. Mevalonate-derived product inhibits translation of mRNA and accelerates degradation of enzyme, 1. Bioi. Chem. 263:8929-8937. Nicholson, D. , Thornberry, N. , Vaillancourt, J. , Ding, C. , Griffin, P. , Lazebnik, Y. , Munday, N. , Raju, S. , Smulson, M. , Yu, V. , and Miller, D. , 1995, Identification and inhibition of the ICEICED-3 protease necessary for mammalian apoptosis, Nature 376:37-43. , 1990, Rat liver cholesterol 7a-hydroxylase: Pretranslational regulation for circadian rhythm, 1.

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Cholesterol: Its Functions and Metabolism in Biology and Medicine by Simon M. Jackson, Johan Ericsson, Peter A. Edwards (auth.), Robert Bittman (eds.)


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