By J. F. A. P. Miller (auth.), Noel L. Warner, Max D. Cooper, M. G. Hanna Jr. (eds.)
In this present quantity of up to date issues in Immunobiology we've selected to proceed with the multiple-theme procedure that was once built in Volumes 1, three, and five of this sequence. Immunobiology nonetheless exhibits little signal of reducing its lively development expense, yet relatively is constant to develop its variety of pursuits and functions, relatively as new concepts and techniques are tailored from different fields of scientific study. This current quantity displays either a number of of the extra classical parts of immunology now addressed within the mild of latest immunology, and a number of other more moderen instructions which have been taken in different fields. the overall topic of T-cell heterogeneity and features of T-cell subpop ulations is addressed in Chapters 1 and a pair of. the aptitude position of genes of the key histocompatibility advanced in controlling the immune capabilities of T lymphocytes nonetheless is still an enormous unresolved factor in immunogenetics, and the present prestige of this challenge is excellently reviewed via J. F. A. P. Miller. The additional elucidation of useful subpopulations of human T lymphocytes has been rather hampered through the inability of obtainable markers for personality izing and separating such sUbpopulations. a tremendous step during this course has been made via L. Moretta, M. Ferrarini, and M. D. Cooper, who overview their ex perience with Fc-receptor-bearing human T-Iymphocyte populations.
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Additional info for Contemporary Topics in Immunobiology: Volume 8
N. G CELLS IN IMMUNODEFICIENCY DISEASES AND MALIGNANCIES A. G cells may exert an important regulatory control over terminal B-cell differentiation, both numerical and functional imbalances in these T-cell sub populations could conceivably be expected in immunodeficiencies. , 1977). , 1977d). These included patients with infantile agammaglobulinemia, selective IgA deficiency, and common variable hypogammaglobulinemia, a diagnostic category that includes a diverse group of syndromes. , 1977). 38 Lorenzo Moretta et al.
Via the antigen bridge, suppressor T' G cells of a specific clonotype may be activated in this way. Ample demonstration has been provided for the selective antigen specificity of mouse suppressor T cells (see Gershon, 1974; Pierce and Kapp, 1976), but for human suppressor T cells only limited evidence for antigen specificity is so far available (McMichael and Susazuki, 1977). , 1977). Other ways in which two activating signals may be simultaneously delivered to specific T' G cells can be postulated within the context of a network theory of immune response regulation (Jerne, 1976).
This method has proven very reliable and simple. In addition, it offers the great advantage over other, in principle equally suitable, techniques in that the cells forming rosettes can be easily separated from nonrosetting T cells. We used bovine erythrocytes as indicator cells in the rosette system. , 1973). , 1977; R. J. , 1976). 0. G (;'\ ~ • G~ Adherent Cell Removal j Plastic Petri Dish Ficoll-Hypaqu~ -Ficoll-Hypaque _ B-cell-enriched fraction ----+ SRBC_ Rosettes dissociated .. 4---by warming (37°C) and shaking Figure 1.
Contemporary Topics in Immunobiology: Volume 8 by J. F. A. P. Miller (auth.), Noel L. Warner, Max D. Cooper, M. G. Hanna Jr. (eds.)