By Elena V. Grigorenko
A quantum bounce in expertise happened many years in the past with the creation of cDNA arrays which have been built in keeping with the necessity for simultaneous research of the styles of expression of millions of genes. DNA Arrays: applied sciences and Experimental thoughts deals a view of other points of this quickly constructing expertise, together with oligonucleotide and electrochemical arrays. exclusive investigators from academia and offer up to date insights into methodological basics of building of DNA arrays, optimization of hybridization stipulations, using expression info in bioinformatics, various software program instruments, and the applying of microarray know-how for drug discovery procedure.
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Additional info for DNA Arrays: Technologies and Experimental Strategies
Binding of the target sequence to both the capture probe and the signaling probe connects the electronic labels to the surface. In this manner, the complementary binding properties of DNA and RNA are used to assemble an electronic circuit element, generating a detectable electronic signal when the target DNA or RNA is present. When a slight voltage is applied to the sample following hybridization, the labels release electrons, producing a characteristic signal that can be detected through the electrode.
P. , Analysis of gene expression profiles in normal and neoplastic ovarian tissue samples identifies candidate molecular markers of epithelial ovarian cancer, Proc. Natl. Acad. Sci. , 98, 1176–1181, 2001. 32. , Genomic analysis of metastasis reveals an essential role for RhoC, Nature, 406, 532–535, 2000. 33. J. , The use of single nucleotide polymorphism maps in pharmacogenomics, Nat. , 18, 505–508, 2000. 34. , 1337–1348, 1996. 35. , Advantages of 2¢-O-methyl oligoribonucleotide probes for detecting RNA targets, Nucl.
13. , Inversion of in situ synthesized oligonucleotides: improved reagents for hybridization and primer extension in DNA microarrays, Nucl. , 27, 4710–4714, 1999. 14. , Fabrication of patterned DNA surfaces, Nucl. , 24, 3040–3047, 1996. 15. , Maskless fabrication of light-directed oligonucleotide microarrays using a digital micromirror array, Nat. , 17, 974–978, 1999. 16. Beier, M. , Production by quantitative photolithographic synthesis of individually quality checked DNA microarrays, Nucl. , 28, e11, 2000.
DNA Arrays: Technologies and Experimental Strategies by Elena V. Grigorenko