Download PDF by John Morrow (Auth.): Eukaryotic Cell Genetics

By John Morrow (Auth.)

ISBN-10: 0125073607

ISBN-13: 9780125073608

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8). Medrano and Green (1974) have developed a reverse selective system for uridine kinase-deficient mutants similar to the HAT selective system (Fig. 9). IV. DRUGS OTHER THAN PURINE AND PYRIMIDINE ANALOGS A. 3) located on the cell membrane. It is ultimately cytotoxic, and mutants resistant to Drugs O t h e r t h a n P u r i n e a n d P y r i m i d i n e Analogs 29 its effects can be isolated in a single step. Baker et al. (1974) isolated both mouse and Chinese hamster cells resistant to ouabain with a spontaneous rate of 5 x 8 1 0 ~ per cell per generation.

Mutants. 'aAissjUJjaduou 'du i§uup|d ρ ÂDuaprjjg 'd03 q L^/MHa S||9D Jajs -LUELJ ueuAc jpo 9U9JON|JOUILUP pauijojsueji -/V Aq paujjo^supji paiujojsueji S\\BD asnoiu asnoiu paujjo^suEJj-OMS s||aD £J_£ pauiJO-fsupji-OMS £J_£ adAiouaqd uumac aDuapuad -9PU| paiujojsueji adAjouaqd 53 54 A u x o t r o p h i c Variants in C u l t u r e d Cells E. Temperature-Sensitive Variants A final class of variants obtained in cell culture systems bear consideration in this chapter, although not all of them represent auxotrophic gene mutations.

1975a). C. Folic Acid Analogs (Amethopterin and Aminopterin) These substances are inhibitors of the enzyme folic acid reductase (see next chapter) and kill the cell by inhibiting one-carbon metabolism and the de novo pathway of purine and pyrimidine synthesis. Dihydrofolate (DHF, the substrate of the reaction) is reduced to tetrahydrofolate to supply one-carbon units for purine and thymidylate synthesis. 5 (see Chapter 3) shows the structure of folic acid and some of its antagonists. They have proved to be quite useful in cancer chemotherapy, and for this reason, as well as their utility in enlarging our theoretical knowledge, an understanding of resistance to these substances is of great interest.

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Eukaryotic Cell Genetics by John Morrow (Auth.)

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