By Richard Sheardy, Stephen Winkle
content material: Inhibition of g-quadruplex helicase task as decided by way of floor plasmon resonance --
A fluorescence-based quadrukplex dna cleavage assay --
Biophysical reviews of the constitution, balance and ligand binding houses of g-quadruplex dna: ideas and comparisons of the c-myc, bcl-2, and k-ras oncogene promoter series quadruplexes --
A cd spectroscopic research of inter- and intramolecular dna quadruplexes --
Nucleosomal dna: kinked, now not kinked, or self-healing fabric --
the scale of inner loops impacts the unfolding thermodynamics of dna hairpins --
A thermodynaic perspectivwe of srns-mrna interactions and the function of hfq --
Protein: feeling the groove of dna --
Chemistry and biology of aflatoxin-dna adducts --
studying flanking series specificity and topological specificity within the binding of varied molecular forms to dnas utilizing limit endonuclease job assays.
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Additional info for Frontiers in Nucleic Acids
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Background It has been proposed that focusing on structural selectivity rather than sequence selectivity, when targeting DNA replication or transcription, is the more promising area of drug design (13). G-quadruplex and i-Motif higher order DNA structures have been the focus of recent strategies for oncogene regulation (13–17). Approximately 40% of all human genes have been found to have i-Motif forming purine and G-quadruplex forming pyrimidine-rich sequences within 1Kb of their start sequences (13, 18).
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Frontiers in Nucleic Acids by Richard Sheardy, Stephen Winkle