Frontiers in Nucleic Acids - download pdf or read online

By Richard Sheardy, Stephen Winkle

ISBN-10: 0841226237

ISBN-13: 9780841226234

ISBN-10: 0841226288

ISBN-13: 9780841226289

content material: Inhibition of g-quadruplex helicase task as decided by way of floor plasmon resonance --
A fluorescence-based quadrukplex dna cleavage assay --
Biophysical reviews of the constitution, balance and ligand binding houses of g-quadruplex dna: ideas and comparisons of the c-myc, bcl-2, and k-ras oncogene promoter series quadruplexes --
A cd spectroscopic research of inter- and intramolecular dna quadruplexes --
Nucleosomal dna: kinked, now not kinked, or self-healing fabric --
the scale of inner loops impacts the unfolding thermodynamics of dna hairpins --
A thermodynaic perspectivwe of srns-mrna interactions and the function of hfq --
Protein: feeling the groove of dna --
Chemistry and biology of aflatoxin-dna adducts --
studying flanking series specificity and topological specificity within the binding of varied molecular forms to dnas utilizing limit endonuclease job assays.

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2010, 277, 3452–3458. ; Balasubramanian, S. Nat. Chem. 2010, 2, 1095–1098. Kim, M. ; Duan, W. ; Hurley, L. H. J. Med. Chem. 2003, 46, 571–583. Duan, W. ; Kim, M. ; Zeng, Q. ; Sun, D. ; Han, H. ; Fedoroff, O. ; Rha, S. ; Von Hoff, D. ; Hurley, L. H. Mol. Cancer Ther. 2001, 1, 103–120. ; ACS Symposium Series; American Chemical Society: Washington, DC, 2011. ch002 30. Han, F. X. ; Wheelhouse, R. ; Hurley, L. H. J. Am. Chem. Soc. 1999, 121, 3561–3570. 31. Han, H. ; Langley, D. ; Hurley, L. H. J. Am.

Background It has been proposed that focusing on structural selectivity rather than sequence selectivity, when targeting DNA replication or transcription, is the more promising area of drug design (13). G-quadruplex and i-Motif higher order DNA structures have been the focus of recent strategies for oncogene regulation (13–17). Approximately 40% of all human genes have been found to have i-Motif forming purine and G-quadruplex forming pyrimidine-rich sequences within 1Kb of their start sequences (13, 18).

Wang, L. ; Johnson, F. B. Nucleic Acids Res. 2008, 36, 144–156. ; Bolt, E. ; Cabezon, E. J. Biol. Chem. 2010, 285, 17537–17544. Cahoon, L. ; Seifert, H. S. Science 2009, 325, 764–767. Parkinson, G. N. , 2006; pp 1–30. Rachwal, P. ; Fox, K. R. Biochemistry 2007, 46, 3036–3044. Olsen, C. ; Gmeiner, W. ; Marky, L. A. J. Phys. Chem. B 2006, 110, 6962–6969. Zheng, K. ; Hao, Y. ; Tan, Z. Nucleic Acids Res. 2010, 38, 327–338. ; Maiti, S. Nucleic Acids Res. 2008, 36, 5610–5622. ; Bolton, P. H. Methods 2007, 43, 324–331.

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