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Embedded local search approaches for routing optimization. Comp and Oper Res, 32, pp. 465490. Efron, B. (1979). Bootstrap method: Another look at the jackknife. Ann. , 7, pp. 1-26. , and Tibshirani, R. (1993). An Introduction to the Bootstrap. Chapman and Hall, New York. Ellis, T. (1997). Neighbour mapping as a method for ordering genetic markers. Genet. Res. , 69, pp. 35-43. Emrich, S. , Wen, T. , Ashlock, D. , and Schnable, P. S. (2004). ) genome. Bioinformatics, 20, pp. 140-147. Falk, C. T.

Wiley, Chichester, pp. 55-66. , and Keuthen, R. (2005). Embedded local search approaches for routing optimization. Comp and Oper Res, 32, pp. 465490. Efron, B. (1979). Bootstrap method: Another look at the jackknife. Ann. , 7, pp. 1-26. , and Tibshirani, R. (1993). An Introduction to the Bootstrap. Chapman and Hall, New York. Ellis, T. (1997). Neighbour mapping as a method for ordering genetic markers. Genet. Res. , 69, pp. 35-43. Emrich, S. , Wen, T. , Ashlock, D. , and Schnable, P. S. (2004).

2004). 4. Re-Sampling Verification of the Obtained Solution The quality of ordering of clones within the contig is characterized not only by the value of the chosen criterion, but also by its robustness to small uncertainty of band content of the clones, that can be referred to as contig stability. To evaluate this stability we use jackknife iterations. Namely, we first construct the order using clone overlaps scored over all bands. In addition, we construct orders using clone overlaps based on randomly selected subsets of bands (95% of the total set).

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