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Additional info for Harper's Textbook of Pediatric Dermatology, Volume 1, 2, Third Edition
7 Embryonic skin from a 54-day EGA human embryo immunostained with the HBM-45 monoclonal antibody, which recognizes an antigen in the melanocyte. (a) Section of skin. Note the abundance and position of these cells within the two-layered epidermis. (b) Epidermal sheet. Note the density, spacing and dendritic morphology of these cells (a, ×350; b, ×25). EGA in general body skin but there is no evidence of melanosomes in the cytoplasm . Langerhans cells are recognized in embryonic skin as early as 42 days EGA on the basis of a reaction product for membrane-bound Mg2+ adenosine triphosphatase (ATPase) and histocompatibility locus antigen (HLA-DR) on the plasma membrane Embryogenesis of the Skin [15–17] and by their truncated or dendritic morphology (Fig.
6 Chapter 2 Fig. 5 Section of skin from a 78-day EGA human fetus showing differential expression of the A-chain of PDGF in the basal and intermediate cell layers (green) and an absence of staining in peridermal cells. The receptor for PDGFA, PDGFR-α (red), is expressed by cells in the dermis (×350). (a) Fig. 6 Scanning electron micrograph of the surface of 55-day EGA embryonic skin from the surface of the developing foot. The layer of cells shown is the periderm. Note the microvilli and the variable size and shape of the cells (×1000).
43 Smith LT, Holbrook KA, Madri JA. Collagens types I, III and V in human embryonic and fetal skin. Am J Anat 1986; 175:507–22. 44 Smith LT, Holbrook KA. Embryogenesis of the dermis. Pediatr Dermatol 1986;3:271–80. 45 Smith LT. Patterns of type VI collagen compared to types I, III, and V collagen in human embryonic and fetal skin and in fetal skinderived cell cultures. Matrix Biol 1994:14:159–70. 46 Breen M, Weinstein HG, Johnson RL et al. Acid glycosaminoglycans in human skin during fetal development and in adult life.
Harper's Textbook of Pediatric Dermatology, Volume 1, 2, Third Edition