Heart Development - download pdf or read online

By Richard P. Harvey and Nadia Rosenthal (Eds.)

ISBN-10: 0123298601

ISBN-13: 9780123298607

  • ebook is kind of whole in scope... the varied illustrations are remarkably good crafted, even stunning. the eye so evidently committed by means of the authors and editors to those explanatory illustrations is esthetically lucrative and should be relatively necessary to readers with little historical past in developmental biology...Serious students and investigators within the box will wish this publication since it is the mose obtainable, authoritative, and entire precis of cardiac improvement at the moment to be had, person who can function a reference for themselves, their scholars, and their laboratory personnel...the sheer fantastic thing about the e-book, the usefulness of the index, and the readability of the illustrations may still offer either info and enjoyment to a large readership.''
    --NEW ENGLAND magazine of drugs (April 1999)


    ''Heart Development is for that reason well timed and significant, and fills a void within the to be had literature... usually such volumes are see you later within the making that they're old-fashioned ahead of they're released. now not this publication. With updated chapters written by means of many famous gurus within the box of cardiac improvement, and transparent, top of the range illustrations (a relatively robust feature), the ebook might be helpful to graduate scholars, investigators within the easy sciences, and clinicians wishing to stick present during this field.''
    --NATURE medication (March 1999)


    ''The 28 chapters in Heart Development are rather well written. The booklet is fantastically produced and includes many glorious diagrams... the quantity is quintessential if you paintings at the heart...''
    --SCIENCE (February 1999)

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Extra info for Heart Development

Example text

1993). Distinct patterns of connexin expression in canine Purkinje fibers and ventricular muscle. Circ. Res. 72, 1124-1131. Kirby, M. L. (1993). Cellular and molecular contributions of the cardiac neural crest to cardiovascular development. Trends Cardiovasc. Med. 3, 18-23. Kirby, M. , and Stewart, D. E. (1983). Neural crest origin of cardiac ganglion cells in the chick embryo: Identification and extirpation. Dev. Biol. 97, 433-443. Lamers, W. , De Jong, E, De Groot, I. J. , and Moorman, A. E M.

These studies provided a detailed description of cardiac morphogenesis and also identified a number of tissue interactions that influenced this process. From a modern perspective, the limitations of this work lie not in the imprecision of the heart field concept itself but rather in the inability of early investigators to distinguish between cellular differentiation and morphogenesis. In reviewing these studies, a further difficulty is the use of several different amphibian species, each with its own staging system and rate of development.

Classical organizer grafts pioneered by Spemann and Mangold (1924) result in axis duplication in which the duplicated heart is derived from host ventral mesoderm. Together, these results indicate that signals from the organizer are essential for specification of heart precursors and that such signals can respecify adjacent mesoderm either after extirpation of the heart-forming regions or after transplantation into the ventral side of the gastrula (Sater and Jacobson, 1990b). Signaling by the organizer, however, is required only early during gastrulation since its removal in mid- and late gastrula stages has no effect on heart formation.

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Heart Development by Richard P. Harvey and Nadia Rosenthal (Eds.)


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