Hepadnaviruses: Molecular Biology and Pathogenesis - download pdf or read online

By J. Israel, W. T. London (auth.), William S. Mason, Christoph Seeger (eds.)

ISBN-10: 3642760155

ISBN-13: 9783642760150

ISBN-10: 3642760171

ISBN-13: 9783642760174

Pioneering paintings on hepatitis B virus and hepatitis delta virus, and the invention of hepatitis B-like virus in animals through the 1970's has been undefined, during the last ten years, by means of an explosion of curiosity in how those viruses mirror, preserve power infections, and reason liver sickness and hepatocellular carcinoma. the aim of this ebook is two-fold. First, the authors of every bankruptcy supply a precis in their uniqueness that may not in basic terms function an advent, yet also will give you the newcomer to hepatitis B virology with updated details and insights into the ambitions and accomplishments of every region of research. moment, because the diversification of pursuits and elevated specialization of hepadnaviruses researchers has reached a degree the place it's now not attainable for anybody person to learn the entire fundamental literature, this ebook may help to refocus curiosity on what's, in the end, the most important target: to appreciate and finally deal with or hinder power liver affliction and liver melanoma. as a result, chapters are integrated which span a number of pursuits, from the administration of hepatitis B sufferers to new techniques to antiviral treatment, from the position of hepadnavirus gene expression in DNA replication to the position of ribozymes within the delta virus lifestyles cycle, from liver melanoma in clearly contaminated woodchucks to liver ailment in HBV transgenic mice to using hepatitis virus vectors to regard inherited enzyme deficiencies.

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Extra info for Hepadnaviruses: Molecular Biology and Pathogenesis

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2 Priming of Plus-Strand DNA Synthesis . . . . . . . . . . . . . . 52 52 53 6 The Viral DNA Polymerase . . . . . . . . . . . . . . . . . . 54 7 Perspectives............................................ 55 References . . . . . . . . . . . . . . . . . . . . . . . . 56 1 Introduction In 1973, it was first discovered that human hepatitis B virus (HBV) preparations from sera of chronically infected individuals contain an endogenous polymerase activity capable of carrying out a repair reaction on the viral DNA template in the presence of magnesium and nucleotide triphosphates (KAPLAN et al.

5 Plus-Strand DNA. . . . . . . . . . . . . . . . . . . . . 1 Structure of Plus-Strand DNA. . . . . . . . . . . . . . . . . 2 Priming of Plus-Strand DNA Synthesis . . . . . . . . . . . . . . 52 52 53 6 The Viral DNA Polymerase . . . . . . . . . . . . . . . . . . 54 7 Perspectives............................................ 55 References . . . . . . . . . . . . . . . . . .

5 Plus-Strand DNA. . . . . . . . . . . . . . . . . . . . . 1 Structure of Plus-Strand DNA. . . . . . . . . . . . . . . . . 2 Priming of Plus-Strand DNA Synthesis . . . . . . . . . . . . . . 52 52 53 6 The Viral DNA Polymerase . . . . . . . . . . . . . . . . . . 54 7 Perspectives............................................

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Hepadnaviruses: Molecular Biology and Pathogenesis by J. Israel, W. T. London (auth.), William S. Mason, Christoph Seeger (eds.)


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