By Leslie Collier, John Oxford
Viruses are the smallest of organisms, but provided that they account for no less than a 3rd of displays within the medical professionals health center, they need to be good understood via scientific scholars and practitioners alike. Collier & Oxford's Human Virology offers this advanced and swiftly evolving topic with amazing readability and topicality. the 1st a part of the textual content bargains with the overall ideas of virology, together with the homes of viruses, replication and genetics, in addition to disorder and resistance. this can be by way of chapters devoted to particular teams of viruses, then exact syndromes linked to vulnerable teams. the ultimate a part of the publication is reserved for sensible elements of virology, together with analysis, regulate measures and anti-viral cures. The authors reason isn't really to show their readers into virologists, yet relatively to supply them with adequate wisdom of the character of viruses and viral infections to function a vital starting place for scientific involvement with the topic. by way of delivering a concise yet entire account of the attention-grabbing topic of virology, this article is perfect for college kids of medecine, dentistry, microbiology, nursing and the organic sciences. This newest variation has been largely up to date and contains many new diagrams, observed by way of the advent of complete color presentation. the significance of viruses has demanded a clean appreciation lately, supplying chance for this version to incorporate assurance of: - The emergence of SARS - most up-to-date examine within the research of prion illnesses - An exploration of the controversy concerning MMR as opposed to unmarried vaccination - growth within the research and remedy of HIV/AIDS - fresh advances in diagnostic virology and antiviral remedy - larger emphasis at the antiviral precautions required of healthcare pros
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Extra info for Human Virology (3rd Edition)
Lytic viruses, for example polio, are released on lysis and death of the cell. g. inﬂuenza, HIV, and measles) escape by budding from the cell surface. Viral proteins are transported by the existing cell machinery and are, in the case of ‘budding’ viruses, inserted in the external plasma membrane of the cell; other virus structural proteins migrate to the inside of the plasma membrane. The proteins and nucleic acids selfassemble, and viral RNA or DNA is packaged as the completed virion buds by protrusion through the cellular plasma mem- HV3E_03(19-28) 5/5/06 5:20 PM Page 27 3 Viral replication and genetics brane.
Respiratory symptoms are an excellent example. Members of ﬁve families of viruses cause cough, sore throat, and runny nose. As may be imagined, this can create problems in diagnosis, most of which can, however, be solved by studying the clinical picture as a whole and enlisting the aid of the virology laboratory as early in the illness as possible. 1 A little ‘non-human’ virology So far, in line with the intention of this book, we have considered only viruses that infect humans or other mammalian or avian species that interact with them.
Viral messages may also be read in different reading frames at the translation stage, again allowing more extensive use of viral genetic information. • Control of viral gene expression occurs at four levels: • conﬁguration of viral DNA or RNA, HV3E_03(19-28) 28 5/5/06 5:20 PM Page 28 1 General principles • at transcription itself (rate of initiation, utilization of upstream transcription factors); • mRNA half-life, splicing of mRNA precursors, and ﬂow of mRNA from the nucleus; and • at translation.
Human Virology (3rd Edition) by Leslie Collier, John Oxford