Get In Search of Mechanisms: Discoveries across the Life PDF

By Carl F. Craver, Lindley Darden

Neuroscientists examine the mechanisms of spatial reminiscence. Molecular biologists learn the mechanisms of protein synthesis and the myriad mechanisms of gene legislation. Ecologists research nutrient biking mechanisms and their devastating imbalances in estuaries equivalent to the Chesapeake Bay. in truth, a lot of biology and its background consists of biologists developing, comparing, and revising their figuring out of mechanisms.

With In seek of Mechanisms, Carl F. Craver and Lindley Darden provide either a descriptive and an academic account of ways biologists detect mechanisms. Drawing on examples from around the lifestyles sciences and during the centuries, Craver and Darden collect a magnificent toolbox of recommendations that biologists have used and should use back to bare the mechanisms that produce, underlie, or continue the phenomena attribute of dwelling issues. They speak about the questions that determine within the look for mechanisms, characterizing the experimental, observational, and conceptual concerns used to respond to them, all of the whereas delivering examples from the heritage of biology to focus on the categories of proof and reasoning suggestions hired to evaluate mechanisms. At a deeper point, Craver and Darden pose a scientific view of what biology is, of ways biology makes development, of ways organic discoveries are and may be made, and of why wisdom of organic mechanisms is necessary for the way forward for the human species.

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Haematol. 47:553-561, 1981. Savage RA, Hoffman GC, Lucas FV: Morphology and cytochemistry of microgranular acute promyelocytic leukemia (M3m). Am. J. Clin. Pathol. 75:548-552, 1981. Golomb HM, Rowley JD, Vardiman JW, Testa JR, Butler A: nMicrogranular n acute promyelocytic leukemia: A distinct clinical, ultrastructural, and cytogenetic entity. Blood 55:253-259, 1980. Dick FR, Armitage JO, Burns CP: Diagnostic concurrence in the subclassification of adult acute leukemia using FrenchAmerican-British criteria.

Yunis JJ: The chromosomal basis of human neoplasia. Science 221:227-236, 1983. Flandrin G, Brouet JC, Daniel MT, Preud'homme JL: Acute leukemia with Burkitt's tumor cells: A study of six cases with special reference to lymphocyte surface markers. Blood 45:183-188, 1975. Palutke M, Tabaczka P: Cytochemical and immunological aspects of the acute lymphocytic leukemias (as related to FAB classification). Ann. Clin. Lab. Sci. 10:269-275, 1980. Borella L, Sen L: E receptors on blasts from untreated acute lymphocytic leukemia (ALL): Comparison of temperature dependence of E rosettes formed by normal and leukemic lymphoid cells.

BIOCHEMICAL MODULATION. Each of these concepts are discussed below. Two-drug combinations were first examined in the early days of experimental chemotherapy with the idea of controlling the development of drug resistance following single agent therapy (56), however, it became obvious that positive (synergistic) interactions could occur between agents to increase their effectiveness (57). This led to extensive studies over the years examining nearly every conceivable two-drug combination for interaction as generally defined in terms of increased survival time of leukemia-bearing mice.

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In Search of Mechanisms: Discoveries across the Life Sciences by Carl F. Craver, Lindley Darden


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