By Craig Davis, Steven R. Harris
Those are Adobe Clearscan PDF documents generated from six hundred dpi scans of the Kaplan USMLE Step 1 Lecture Notes which have been allotted to scholars in Kaplan scientific prep classes in 2014.
The following preface references 7 volumes. This includes simply the Pharmacology volume.
These 7 volumes of Lecture Notes characterize the most-likely-to-be-tested fabric at the present USMLE Step 1 examination. Please observe that those are Lecture Notes, now not evaluate books. The Notes have been designed to be observed through school lectures reside, on video, or on the internet. analyzing them with out gaining access to the accompanying lectures isn't a good way to study for the USMLE.
To maximize the effectiveness of those Notes, annotate them as you take heed to lectures. To facilitate this procedure, we've created large, clean margins. whereas those margins are sometimes punctuated by means of school high-yield "margin notes:' they're, for the main half, left clean in your notations.
Many scholars locate that previewing the Notes ahead of the lecture is a truly effective solution to arrange for sophistication. this lets you count on the components the place you'll have to pay specific consciousness. It additionally offers you the chance to map out how the knowledge goes to be awarded and what kind of examine aids (charts, diagrams, etc.) you want to upload. This process works whether you're attending a dwell lecture or looking at one on video or the web.
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Additional info for Kaplan Medical USMLE Step 1 Lecture Notes: Pharmacology (2013)
12 h c. 14 h D. 16 h E. 24 h Which statement is accurate for the drug shown in the example below? 5 mg 12. A. The rate of elimination is constant B. The elimination half-life varies with the dose C. The volume of distribution varies with the dose D. The clearance varies with the dose E. The rate of elimination varies directly with the dose Normally, acetaminophen has a Vd = 70L and Cl = 350 mL/min. If acet aminophen was administered to a patient with 50% renal function, what parameter would differ from normal?
18 � MEDICAL Pharmacodynam ics 2 DEFINITIONS • Pharmacodynamics relates to drugs binding to receptors and their effects. • Agonist: A drug is called an agonist m when binding to the receptor results a response. Antagonist: A drug is called an antagonist when binding to the receptor is • not associated with a response. The drug has an effect only by preventing an agonist from binding to the receptor. Affinity: • ability of drug to bind to receptor, shown by the proximity of the curve to they axis (if the curves are parallel); the nearer they axis, the greater the affinity Potency: shows relative doses of two or more agonists to produce the same • magnitude of effect, again shown by the proximity of the respective curves to they axis (if the curves do not cross) Efficacy: • a measure of how well a drug produces a response (effective ness), shown by the maximal height reached by the curve GRADED (QUANTITATIVE) DOSE-RESPONSE (D-R) CURVES Plots of dose (or log dose) versus response for drugs Bridge to Biochemistry (agonists) that activate recep tors can reveal information about affinity, potency, and efficacy of these agonists.
As the partial agonist displaces the full agonist from the receptor, the response is reduced-the partial agonist is acting as an antagonist. Antagonism and Potentiation • Graded dose-response curves also provide information about antago nists-drugs that interact with receptors to interfere with their activa tion by agonists. Control 100 Q) (/) c 0 Q. (/) Q) a: #Log dose of drug Compe titive j Figure 1-2-4. J, the potency of the agonist affinity (i Km) response but not maximal (Vmax remains the same).
Kaplan Medical USMLE Step 1 Lecture Notes: Pharmacology (2013) by Craig Davis, Steven R. Harris