Medullary Thyroid Carcinoma: Biology – Management – by Friedhelm Raue PDF

By Friedhelm Raue

ISBN-10: 3319225413

ISBN-13: 9783319225418

ISBN-10: 3319225421

ISBN-13: 9783319225425

This booklet bargains a accomplished evaluation of medullary thyroid carcinoma, either within the extra universal sporadic shape and within the familial shape, a number of endocrine neoplasia (MEN) kinds 2A and 2B. The assurance comprises, yet isn't really constrained to, molecular biology and genetics, pathology, medical presentation, imaging ideas, surgical procedure, and follow-up. The position of calcitonin as a hugely delicate and particular tumor marker for the screening, analysis, and follow-up of MTC and metastatic ailment is defined, and the importance of alternative tumor markers can be thought of. with reference to therapy, using thyroidectomy is absolutely mentioned, together with in childrens wearing the mutations within the RET proto-oncogene thought of causative for males 2. also, the worth of tyrosine kinase inhibitors because the foremost remedy modality in sufferers with a wide tumor burden or quick tumor progress, or either, is defined. Medullary Thyroid Carcinoma and a number of Endocrine Neoplasia kind 2 should be an amazing resource of updated details for quite a lot of practitioners, together with endocrinologists, oncologists, inner medication experts, geneticists, and nuclear medication physicians.

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Folia Anat Jpn 1:69 Takahashi C, Contreras B, Iwanaga T, Takegami Y, Bakker A, Bronson RT, Noda M, Loda M, Hunt JL, Ewen ME (2006) Nras loss induces metastatic conversion of Rb1-deficient neuroendocrine thyroid tumor. Nat Genet 38(1):118–123. 1038/ng1703 Tauber SD (1967) The ultimobranchial origin of thyrocalcitonin. Proc Natl Acad Sci USA 58 (4):1684–1687 Testaz S, Jarov A, Williams KP, Ling LE, Koteliansky VE, Fournier-Thibault C, Duband JL (2001) Sonic hedgehog restricts adhesion and migration of neural crest cells independently of the Patched- Smoothened-Gli signaling pathway.

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1203648 Agrawal N, Jiao Y, Sausen M, Leary R, Bettegowda C, Roberts NJ, Bhan S, Ho AS, Khan Z, Bishop J, Westra WH, Wood LD, Hruban RH, Tufano RP, Robinson B, Dralle H, Toledo SP, Toledo RA, Morris LG, Ghossein RA, Fagin JA, Chan TA, Velculescu VE, Vogelstein B, Kinzler KW, Papadopoulos N, Nelkin BD, Ball DW (2013) Exomic sequencing of medullary thyroid cancer reveals dominant and mutually exclusive oncogenic mutations in RET and RAS. J Clin Endocrinol Metab 98(2):E364–E369. 2012-2703 Ahlgren SC, Bronner-Fraser M (1999) Inhibition of sonic hedgehog signaling in vivo results in craniofacial neural crest cell death.

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Medullary Thyroid Carcinoma: Biology – Management – Treatment by Friedhelm Raue


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