New PDF release: Molecular Biology and Evolution of Blood Group and MHC

By Colin P. Groves (auth.), Antoine Blancher MD, PhD, Jan Klein PhD, Wladyslaw Socha MD (eds.)

ISBN-10: 3642590861

ISBN-13: 9783642590863

ISBN-10: 3642638430

ISBN-13: 9783642638435

The booklet offers up to date summaries at the major structures of blood workforce antigens and MHC molecules in nonhuman primates. for every method, the human antigens are defined and used as a reference for comparability with their opposite numbers in apes and monkeys. The emphasis is at the molecular constitution of the gene items, the evolutionary pathways and presumed mechanisms wherein the platforms have advanced. All articles are written in the sort of manner that they could function an creation to the sector for nonexperts and, even as, as a guide for specialists. a variety of tables, diagrams, and figures offer overviews of antigen buildings and their distribution in numerous species and evolutionary relationships. huge reference lists consultant the reader throughout the literature on every one topic.

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Extra info for Molecular Biology and Evolution of Blood Group and MHC Antigens in Primates

Sample text

The red cells of Old World monkeys (Cercopithecidae) investigated in the same series of experiments failed to react with any of the reagents, and therefore, were presumed to be devoid of any ABO blood group antigens. However, Wiener et al. demonstrated that the secretions and glands of all lower monkeys regularly contained blood group substances, A or Band Hand that these could be used for the ABO typing (Wiener et al. 1942). As proposed by Wiener and his coworkers (Wiener et al. 1942), saliva inhibition, together with the reverse testing of serum for anti-A and anti-B isoagglutination, became the standard procedure for ABO typing of primate species below the taxonomic level of anthropoid apes.

ABO Blood Groups in Nonhuman Primates . . ......... Tests for ABO, H and Lewis Blood Groups ... . . . . . The ABO Blood Group System of Apes . . . . . . Chimpanzee . . . . . . . . . . Gibbons and Siamangs . . . Orangutans . . . . . . . . . . . . . . . . . . . Gorillas . . . . . . . . . . . . . ......... The ABO Blood Group System of Monkeys . . . . . . . . . Old World Monkeys . . . . . . . . . . . .

Although all these antibodies are developed in response to external antigens, the functional properties of natural anti-A and anti-B antibodies produced by type 0 individuals differ from those produced by type A or type B individuals (Salmon et al. 1984). The serum of type 0 individuals contains antibodies reacting with A or B antigens (anti A + B). The natural antibodies differ from the "immune" type antibodies by their class and their affinities for the antigen (Filitti-Wurmser 1976; Salmon et al.

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Molecular Biology and Evolution of Blood Group and MHC Antigens in Primates by Colin P. Groves (auth.), Antoine Blancher MD, PhD, Jan Klein PhD, Wladyslaw Socha MD (eds.)


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