Molecular Biology and Pathogenesis of Coronaviruses by Brian W. J. Mahy (auth.), P. J. M. Rottier, B. A. M. van der PDF

By Brian W. J. Mahy (auth.), P. J. M. Rottier, B. A. M. van der Zeijst, W. J. M. Spaan, M. C. Horzinek (eds.)

ISBN-10: 1461593735

ISBN-13: 9781461593737

ISBN-10: 1461593751

ISBN-13: 9781461593751

The current quantity includes the lawsuits of an EMBO Workshop geared up in June 1983 through the Institute of Virology, Veterinary college, kingdom collage of Utrecht, The Netherlands. a few 70 scientists from eleven international locations the invitation to give and speak about their contemporary information at the constitution, replication, genetics and pathogenesis of coronaviruses. It was once the second one foreign assembly on those viruses; the Workshop, which was once held in Zeist close to Utrecht the instance of the Wuerzburg symposium of October 1980. at the moment it turned transparent that coronaviruses are particular in lots of respects. as soon as a gaggle of viruses that have been outlined purely at the foundation in their attribute peplomer morphology, Coronaviridae family are identified this day - to be created from primarily 3 polypeptides - to exploit a "nested set" of 5-6 subgenomic mRNAs within the expression in their huge, optimistic and unmarried stranded RNA genome, - to generate those subgenomic RNAs via particular fusion of non­ contiguous sequences, - to mature through budding from intracellular membranes, - to reason power an infection with neurological involvement and infrequently immunopathological conditons. those and plenty of different findings were verified basically very lately. The articles accumulated during this booklet demonstrate and/or additional aspect those findings. on account that those court cases include the mixed clinical displays of representatives from almost all laboratories engaged within the box, they supply a reasonably accomplished overview of the cutting-edge in corona­ virology.

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8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. 20. 21. B. Lomniczi and I. Kennedy, J. Virol. 24:99-107 (1977). F. T. Kennedy, J. Virol. 34:665-674 (1980). F. T. Kennedy, J. Virol. 36:440-449 (1980). S. Siddell, H. Wege, and V. ter Meulen, Curro Topics in Microbiol. and Immunol. 99:131-163 (1982). S. V. Holmes, Adv. Virus Res. 28, in press (1983). F. Stern, L. M. Sefton, J. Virol. 42:208-219 (1982). F. M. Sefton, J. Virol. 44:804-812 (1982). D. Cavanagh, J. Gen. Virol. 53:93-103, (1981). A. R. Howard, J.

RNAs and corresponding translation products from gradient fractions 38 to 47 are shown. RNA in fraction 41 was evidently lost during handling. 19 ORGANIZATION OFTHE IBV GENOME , RNA TRANSLATION PRODUCTS -11 Okd - 51 RNA E- DCB- - 23 Aa b Fig. 4. In vitro translation of gr~dient-purified RNA E. Polyadenylated RNA, labeled with H-uridine, was isolated from infected cells. The RNA was fractionated under the conditions described in the legend to Fig. 3. A portion of the RNA was analyzed by agarose gel electrophoresis and fractions containing RNA E were pooled.

Gen. Virol. 64:113-125 (1983). C. D. Patton. S. A. Stohlman, J. Virol. 46:1027-1033 (1983). W. Spaan, P. Rottier, S. Smeekens. M. Van der Zeijst, H. Delius, J. Armstrong, M. Skinner. G. Siddell. submitted for publication. PROTEOLYTIC CLEAVAGE OF PEPLOMERIC GLYCOPROTEIN E2 OF MHV YIELDS TWO 90K SUBUNITS AND ACTIVATES CELL FUSION Lawrence S. Sturman1 and Kathryn V. Holmes 2 1Center for Laboratories and Research New York State Department of Health Albany, New York 12201 2Department of Pathology, The Uniformed Services University of the Health Sciences Bethesda, Maryland 20814 INTRODUCTION During the past decade our laboratories have been studying the structure and functions of coronavirus glycoproteins.

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Molecular Biology and Pathogenesis of Coronaviruses by Brian W. J. Mahy (auth.), P. J. M. Rottier, B. A. M. van der Zeijst, W. J. M. Spaan, M. C. Horzinek (eds.)


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