Get Molecular Biology of Diabetes: I. Autoimmunity and Genetics; PDF

By Massimo Pietropaolo, George S. Eisenbarth (auth.), Boris Draznin MD, PhD, Derek LeRoith MD, PhD (eds.)

ISBN-10: 1461202418

ISBN-13: 9781461202417

ISBN-10: 1461266777

ISBN-13: 9781461266778

In a swiftly evolving and intensely very important zone of clinical technological know-how, it's always tough for the coed, instructor, and researcher to maintain abreast of all of the very important advances. the aim of Molecular Biology ofDiabetes, elements I and II is to convey to those members the most recent wisdom of diabetes-related learn in a accomplished, but concise demeanour. To this finish, we've got assembled chapters, written through many of the world's specialists within the box, that we think compre­ hensively survey and synthesize a coherent figuring out of the topic. reviews of the etiology of style I and sort II diabetes are tremendous fascinating and crucial, for the reason that we are hoping to 1 day hinder the illness utilizing gene treatment. those points are coated in Molecular Biology of Diabetes: I. Autoimmunity and Genetics; Insulin Synthesis and Secretion. In style II diabetes, an abnormality in pancreatic secretion exists concomitantly with peripheral insulin resistance. This abnor­ mality of insulin secretion is assumed to be with regards to a defect(s) in glucose sensing. Uncoupling of glucose sensing from insulin secre­ tion could be the the most important step within the pathogenesis of noninsulin-depen­ dent diabetes. during this quantity, we've got invited authors to explain their reviews on all identified components affecting ~-cell functionality, together with autoimmunity and genetics of diabetes, in addition to molecular mecha­ nisms of insulin synthesis and secretion. within the previous few years, the main quickly advancing sector of analysis in diabetes has been, in truth, on the topic of insulin action.

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Additional resources for Molecular Biology of Diabetes: I. Autoimmunity and Genetics; Insulin Synthesis and Secretion

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Keller RJ, Eisenbarth GS, Jackson RA: Insulin prophylaxis in individuals at high risk of type I diabetes. Lancet 341 :927-928, 1993. Appel MC, Dotta F, O'Neill J, Eisenbarth GS: Beta cell activity regulates the expression ofislet antigen determinant. Diabetologia 32:461A (abstract), 1989. Anderson GD, Banerjee S, Luthra HS, David CS: Role of Mls-l locus and clonal deletion of T cells in susceptibility to collagen-induced arthritis in mice. J ImmunoI147:1189-1193, 1991. : Induction of type 1 diabetes by Kilham's rat virus in diabetes-resistant BBlWor rats.

Adv /mmunol 51 :285-322, 1992. 21. /nt J /mmunopharmacology 14:451-455, 1992. 22. Newgard CB: Cellular engineering for the treatment of metabolic disorders: prospects for therapy in diabetes. BiotechnoI1O:1112-1120, 1992. 23. Eisenbarth GS: Type I diabetes mellitus. A chronic autoimmune disease. N Engl J Med 314:1360-136, 1986. 24. Baekkeskov S, Hansen B: Human diabetes. Curr Topics Microbiollmmunol 164:1-193, 1990. 25. Bucchini D, Ripoche M-A, Stinnakre MG, Desbois P, Lore D, Montehioux E, Absil I, Lepesant I-A, Pictet R, Iami I: Pancreatic expression of human insulin gene in transgenic mice.

J Immunoll50:166A (abstract), 1993. Targets of Type I Diabetes 31 48. : Combined analysis of autoantibodies enhances prediction ofIDDM in islet cell antibody (ICA) positive relatives. Autoimmunity (suppl):67 (abstract), 1993. 49. Eisenbarth GS, Verge CF, Allen H, Rewers MJ: Perspectives in diabetes: The design of trials for the prevention of IDDM. Diabetes 42:941947, 1993. 50. Maul 00, French BT, van Venrooij WJ, Jimenez SA: Topoisomerase I identified by scleroderma 70 antisera: enrichment of topoisomerase I at the centromere in mouse mitotic cells before anaphase.

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Molecular Biology of Diabetes: I. Autoimmunity and Genetics; Insulin Synthesis and Secretion by Massimo Pietropaolo, George S. Eisenbarth (auth.), Boris Draznin MD, PhD, Derek LeRoith MD, PhD (eds.)


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