Download e-book for iPad: Molecular Biology of the Gene (International Ed.) by James D., Baker, Tania A., Bell, Stephen P., Gann, A

By James D., Baker, Tania A., Bell, Stephen P., Gann, A Watson

ISBN-10: 0321223683

ISBN-13: 9780321223685

ISBN-10: 080534635X

ISBN-13: 9780805346350

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Additional resources for Molecular Biology of the Gene (International Ed.)

Example text

Such a change in shape can be triggered by the binding of an­ other protein or a small molecule such as a sugar. In other cases, an al­ losteric effect can be induced by a covalent modification. For exam­ ple, attaching one or more phosphate groups to a protein can trigger a change in the shape of that protein. Another way a protein can be con­ trolled is by regulating when it is brought into contact with a target molecule. In this way a given protein can be recruited to work on dif­ ferent target proteins in response to different signals.

MacLeod and Maclyn McCarty. made the momentous announcement that the active genetic principle was DNA (Figure 2-2). Supporting their conclusion were key experiments showing that the transforming activity of their highly purified active fractions was destroyed by pancreatic deoxyribonuclease, a recently purified enzyme that specifically degrades DNA molecules to their nucleotide building blocks and has no effect on the integrity of protein molecules or RNA. The addition of either pancreatic ribonu­ clease (which degrades RNA) or various proteolytic enzymes (protein­ destroying) had no influence on the transforming activity.

Thus, in one conformation, a given protein may perform a specific enzymatic function, or bind a specific target molecule. In another conformation, however, it may lose that ability. Such a change in shape can be triggered by the binding of an­ other protein or a small molecule such as a sugar. In other cases, an al­ losteric effect can be induced by a covalent modification. For exam­ ple, attaching one or more phosphate groups to a protein can trigger a change in the shape of that protein. Another way a protein can be con­ trolled is by regulating when it is brought into contact with a target molecule.

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Molecular Biology of the Gene (International Ed.) by James D., Baker, Tania A., Bell, Stephen P., Gann, A Watson


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