Molecular Themes in DNA Replication - download pdf or read online

By Lynne S. Cox

ISBN-10: 0854041648

ISBN-13: 9780854041640

DNA replication, the method of copying one double stranded DNA molecule to shape exact copies, is extremely conserved on the mechanistic point throughout evolution. attention-grabbing in its personal correct as a desirable feat of biochemical rules and coordination, DNA replication is on the middle of contemporary advances in molecular biology. An knowing of the method at either the organic and chemical point is vital to constructing new concepts in molecular biology. Insights into the method on the molecular point supply possibilities to modulate and interfere in replication. swiftly dividing cells have to mirror their DNA sooner than department, and focusing on parts of the replication procedure is a in all probability strong approach in melanoma remedy. Conversely, aging should be linked to lack of replication job and restoring it to cells may well reasonable a number of the illnesses linked to outdated age. Replication is, as a result, primary to an immense variety of molecular organic and biochemical functions, and offers many power pursuits for drug layout. the short velocity of replication study, relatively in supplying new structural insights, has superseded the vast majority of on hand texts. This discovered, but available, ebook includes the newest examine written through these undertaking it. It examines conserved issues supplying a organic heritage for biochemical, chemical and pharmaceutical stories of this massive and interesting box. instead of easily "itemising" the replication steps and the proteins concerned, replication is tackled from a unique viewpoint. The e-book offers logical groupings of approaches dependent upon biochemical similarities. The emphasis on mechanisms and the connection among constitution and serve as goals the chapters in the direction of biochemists and organic chemists in addition to molecular and mobilephone biologists. The ebook highlights new insights into the replication technique, from the meeting of pre-replication complexes, via polymerisation mechanisms, to contemplating replication within the context of chromatin and chromosomes. It additionally covers mitochondrial DNA replication, and contains archaeal paradigms, that are proving more and more suitable to the learn of replication in better eukaryotes. fascinating capability drug objectives in DNA replication are mentioned, quite within the context of treating malaria and melanoma.

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Hubscher, Proliferating cell nuclear antigen (PCNA): a dancer with many partners, J. , 2003, 116, 3051–3060. 76. G. Krings and D. Bastia, Molecular architecture of a eukaryotic DNA replication terminus–terminator protein complex, Mol. Cell. , 2006, 26, 8061–8074. 77. R. A. Poot, L. Bozhenok, D. L. van den Berg, S. Steffensen, F. Ferreira, M. Grimaldi, N. Gilbert, J. Ferreira and P. D. Varga-Weisz, The Williams syndrome transcription factor interacts with PCNA to target chromatin remodelling by ISWI to replication foci, Nat.

Sternglanz and J. Leatherwood, Control of replication timing by a transcriptional silencer, Curr. , 2002, 12, 869–875. F. Li, J. Chen, M. Izumi, M. C. Butler, S. M. Keezer and D. M. Gilbert, The replication timing program of the Chinese hamster beta-globin locus is established coincident with its repositioning near peripheral heterochromatin in early G1 phase, J. , 2001, 154, 283–292. P. Heun, T. Laroche, M. K. Raghuraman and S. M. Gasser, The positioning and dynamics of origins of replication in the budding yeast nucleus, J.

Manak, S. Zhou, M. Bell, J. S. Lipsick and M. R. Botchan, Role for a Drosophila Myb-containing protein complex in sitespecific DNA replication, Nature, 2002, 420, 833–837. 43. R. Lebofsky, R. Heilig, M. Sonnleitner, J. Weissenbach and A. Bensimon, DNA replication origin interference increases the spacing between initiation events in human cells, Mol. Biol. Cell, 2006, 17, 5337–5345. 44. P. J. Gillespie, A. Li and J. J. , 2001, 2, 15. 45. S. E. Moyer, P. W. Lewis and M. R. Botchan, Isolation of the Cdc45/Mcm27/GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicase, Proc.

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Molecular Themes in DNA Replication by Lynne S. Cox

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