By Bruce C. Baguley (auth.), Jun Zhou (eds.)
With the devastating hassle of melanoma cells changing into concurrently immune to many structurally and mechanistically unrelated medications, the efficacy of chemotherapeutic administration of melanoma frequently turns into critically constrained. In Multi-Drug Resistance in Cancer, top researchers within the box offer complete and updated studies of multidrug resistance mechanisms, from over-expression of ATP-binding cassette drug transporters comparable to P-glycoprotein, multidrug resistance-associated proteins, and breast melanoma resistance protein, to the drug ratio-dependent antagonism and the paradigm of melanoma stem cells. The wide quantity additionally contains suggestions to beat multidrug resistance, from the advance of compounds that inhibit drug transporter functionality to the modulation of transporter expression, in addition to recommendations for detection and imaging of drug transporters, equipment for research of drug resistance in animal types, and techniques to guage the efficacy of resistance reversal brokers. As a quantity within the hugely profitable Methods in Molecular Biology™ sequence, this paintings offers the type of targeted description and implementation recommendation that's an important for buying optimum results.
Authoritative and state of the art, Multi-Drug Resistance in Cancer deals a state-of-art number of studies and strategies for either simple and clinician investigators who're drawn to the important examine of melanoma multi-drug resistance mechanisms and reversal strategies.
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Extra info for Multi-Drug Resistance in Cancer
It is an important downstream 26 Nagengast et al. ). Therefore, VEGF could potentially serve as a representative biomarker for early prediction of these targeted therapies. Furthermore, VEGF imaging could give insight in drug resistance. For example, acquired resistance in a breast cancer xenograft model for trastuzumab was associated with increased expression of VEGF (79). Treatment with bevacizumab in this setting, and thus lowering the increased VEGF levels, could overcome resistance for trastuzumab, which resulted in delayed tumor progression.
For cell sorting we use a BD FACSaria sorter with a 100-µm nozzle and reduced pressure (20 psi). 4. 4. Syngeneic Wild-Type Female Animals Bearing Mammary Tumors Through Orthotopic Grafting of Cell Lines Derived from Spontaneous GEMM Mammary Tumors Alteration of genes that confer drug resistance can be carried out in mammary tumor cell lines derived from GEMMs for breast cancer. Instead of the time- and resource-consuming generation of compound mouse models, one can try to transplant modified cell lines orthotopically into syngeneic hosts.
1007/978-1-60761-416-6_3, © Humana Press, a part of Springer Science + Business Media, LLC 2010 33 34 Rottenberg, Pajic and Jonkers cells is the induction of apoptosis/senescence, it has been postulated that abrogation of cell death pathways may also affect the action of anticancer drugs (6–10). The relevance of each of these mechanisms in real human tumors, however, usually remains to be determined. To study the contribution of specific mechanisms to drug resistance in an in vivo setting, mouse models that mimic human cancer are useful.
Multi-Drug Resistance in Cancer by Bruce C. Baguley (auth.), Jun Zhou (eds.)