By Lin Wang, Stefan Wolfl, Minghu Jiang
This publication introduces a brand new biochip that comes with mobile localization and bioinformatics applied sciences. With the post-genome period, proteomics examine for direct research of a bunch of proteins by way of biochip turns into increasingly more vital. With this ebook and its 50 tables and figures, the reader cannot simply find out about new applied sciences but in addition approximately mobile localization, signaling pathways, and protein relationships.
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Additional info for New Antibody Microarray Tube for Cellular Localization and Signaling Pathways
From this result, it can be deduced that the spatial control of cell cycle is through the retention of p-p70S6 in the cytoplasm, thereby preventing them from physical contact with their substrates or partners. The BMP2 signaling pathway is involved in the control of apoptosis, most likely through mechanisms involving the nuclear inhibition by nuclear export in p70S6/Akt PI3K signaling in U937 cells. In this study, the same positive signaling pathway proteins were often observed in the same cytoplasmic and nuclear-change pattern of phosphorylated proteins, such as increasing nucleus or cytoplasm, or increasing or decreasing nucleus and cytoplasm, etc; whereas, total phosphorylated proteins can appear changed or unchanged, such as one increasing, the other unchanged, while the function of these proteins appears identical.
The kinase was reactivated 10-fold when the cells released from a nocodazole-induced metaphase block, entering the G1 of the next cell cycle. The p70S6K activity is dependent on permanent signaling from growth factors at all stages of the cell cycle. Immunofluorescence studies showed that p70S6K becomes concentrated at localized spots in nucleus, at certain stages in the cell cycle. ” From this result, it can be deduced that the spatial control of cell cycle is through the retention of p-p70S6 in the cytoplasm, thereby preventing them from physical contact with their substrates or partners.
Antibody-microarray analysis of p-Akt, untreated (a, c) and treated (b, d) with 2000 ng/ml BMP2 for 3 days. (a, b) Cytoplasm and (c, d) Nucleus. Position of p-Akt antibody is marked with frame and arrow. (e) Graphic display of numerical value analysis. The BMP2-treated U937 cells displayed the increase in cytoplasm and slight decrease in nucleus. Total protein (sum of cytoplasm and nucleus) level of p-Akt is higher in BMP2-treated U937 cells than in control cells. Each column indicates a mean of four measurements with standard deviations.
New Antibody Microarray Tube for Cellular Localization and Signaling Pathways by Lin Wang, Stefan Wolfl, Minghu Jiang