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By Paul D. Boyer

ISBN-10: 0121227154

ISBN-13: 9780121227159

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And Khorana, H. G . (1970). P N A S 67, 68. 71. Sano, H . , and Feix, G. (1974). Biochemistry 13, 5110. 72. Blake, R. , and Fresco, J. R. (1966). J M B 19, 145. 73. , and Bollurn, F. J. (1967). JACS 89, 4798. 1. DNA LIGASES 17 for an enzyme capable of joining both DNA to DNA and RNA to RNA, the T4 DNA ligase can join RNA to DNA in either orientation (69, 74). Some information on the substrate specificities of DNA ligases from other sources is available. T7 DNA ligase, assayed in crude extracts, is able to join oligo(dT).

R e v . 44, 1 . 24 MICHAEL J. ENGLER AND CHARLES C. RICHARDSON purified from this strain is thermolabile (109, 111). An independently isolated temperature-sensitive mutant, ligts7, has also been shown to be deficient in DNA ligase (111-114). Of the mutations studied, lists7 seems to have the most severe ligase deficiency. The lig4 mutant, which has about 1% of the normal ligase joining activity at 42”, has normal growth rates under all conditions. It is UV-resistant, and is only moderately sensitive to methylmethane sulfonate, indicating that its ability to repair DNA may be less severely impaired (109).

99. , and Hanawalt, P. C. (1968). J M B 39, 639. 100. Hosoda, J . , and Mathews, E. (1968). PNAS 61, 997. 101. Kozinski, A. , and Kozinski, P. B. (1968). BBRC 33, 670. 102. Bernstein, H . (1968). C S H S Q B 33, 325. 103. Kozinski, A. , and Kozinski, P. B. (1969). J . Virol. 3, 85. 104. Anraku, N . , and Lehman, I. R. (1969). JMB 46, 467. 105. Baldy, M. W. (1970). Virology 40, 272. I. DNA LIGASES 23 2. Phage T7 DNA Liguse An amber mutant of phage T7 that fails to induce the T7 DNA ligase was initially obtained by mutagenesis of phage T7 using hydroxylamine (106).

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Nucleic Acids by Paul D. Boyer

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