By Sukhamay Lahiri, Gregg Semenza, Nanduri R. Prabhakar
Reviewing learn at the molecular foundation of oxygen homeostasis, this article describes the adjustments in intracellular signalling and gene expression that result in physiological responses to hypoxia in unicellular, invertebrate, and mammalian species. It examines O2 sensing platforms in micro organism and archaea and demonstrates interrelationships between phone proliferation, strength metabolism, oxygen homeostasis, redox states, sign transduction and gene expression in people and different organisms. The ebook describes the influence of hypoxia on carotid physiology and serve as and the influence of changes in oxygen homeostasis at the pathophysiology of cardiac ischemia, melanoma, stroke, and persistent lung affliction
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Extra info for Oxygen Sensing: Responses and Adaption to Hypoxia
Oxygen as a key developmental regulator of Rhizobium meliloti N2 ﬁxation gene expression within the alfalfa root nodule. Proc Natl Acad Sci USA 1995; 92:3759–3763. 23. Nellen-Anthamatten D, Rossi P, Preisig O, Kullik I, Babst M, Fischer HM, Hennecke H. Bradyrhizobium japonicum FixK2, a crucial distributor in the FixLJ-dependent regulatory cascade for control of genes inducible by low oxygen levels. J Bacteriol 1998; 180:5251–5255. 24. Preisig O, Zufferey R, Thony-Meyer L, Appleby CA, Hennecke H.
The Kaposi’s sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1a. Cancer Res 2000; 60:4873–4880. A. I. Introduction to Heme-Based Sensors ‘‘Heme-based sensors’’ are increasingly appreciated as a broad and important class of heme proteins that detect and transduce physiological O2, CO, or NO signals (1,2). Reversible binding of those ligands to heme iron represents one of the simplest mechanisms for their detection.
34. Lois AF, Weinstein M, Ditta GS, Helinski DR. Autophosphorylation and phosphatase activities of the oxygen-sensing protein FixL of Rhizobium meliloti are coordinately regulated by oxygen. J Biol Chem 1993; 268:4370–4375. 35. Gilles-Gonzalez MA, Gonzalez G, Perutz MF. Kinase activity of oxygen sensor FixL depends on the spin state of its heme iron. Biochemistry 1995; 34:232–236. 36. Tuckerman JR, Gonzalez G, Gilles-Gonzalez MA. Complexation precedes phosphorylation for two-component regulatory system FixL=FixJ of Sinorhizobium meliloti.
Oxygen Sensing: Responses and Adaption to Hypoxia by Sukhamay Lahiri, Gregg Semenza, Nanduri R. Prabhakar