By C. E. Patterson
This readable, accomplished textual content covers endothelial biology from the basics of constitution and lung fluid stability body structure to state of the art descriptions of the molecular mechanisms excited by the advance of lung failure. the cloth and illustrations, supplied via amazing specialists of their person components of analysis and medical focus, is artfully woven jointly to supply the reader with an built-in, in-depth, and updated wisdom of endothelial functionality, vascular integrity, pulmonary functionality, and pathophysiology in breathing failure.
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Extra info for Perspectives on Lung Endothelial Barrier Function
Physiol. 283:L1203-1209. A. (1989) Neutrophil activation and changes in microvascular pressure is acute pulmonary edema. Amer. Rev. Resp. Dis. 140:1052-1062. , and Garcia, J. (1994) Mechanisms of cholera toxin prevention of thrombin-and PMA-induced endothelial cell barrier function. Microvacs. Res. 48:212-235, 1994. E. and Lum, H. (2001) Update on pulmonary edema: the role and regulation of endothelial barrier function. Endothelium 8:75-105. E. L. (1982) The effect of superoxide dismutase on paraquat mortality in mice and rats.
C. Prestressed tensegritv model: This model views the cell cytoskeleton, as analogous to compression bearing struts (pink) attached to tensed cables, which give shape and stability to the cell. It incorporates all elements of the cytoskeleton: the microtubules (struts), actin microfilaments, and intermediate filaments (tensile structures), as well as actomyosin units (cables developing the stabilizing tension). Endothelial activation results in an increase in the pre-existing tension, resulting in stiffening of the cell.
A. (1990) Elevated von Willebrand factor antigen is an early plasma predictor of acute lung injury in nonpulmonary sepsis syndrome. J. Clin. Invest. 86:474-80. S. W. (1984) Cell biology of the pulmonary endothelium. Circ. 70:46-62. E. (1992) Gp60 is an albumin-binding glycoprotein expressed by continuous endothelium involved in albumin transcytosis. Amer. J. Physiol. 262:H246-H254. Schuster, D. (1998) Evaluation of lung function with PET. Seminars in Nuclear Medicine 28:341-351. A. (1987) Cyclooxygenase metabolites contribute to oleic acid-induced lung edema by a pressure effect.
Perspectives on Lung Endothelial Barrier Function by C. E. Patterson