By Erik Dassi (eds.)
This quantity goals to supply the latest advances in options for learning gene expression law on the post-transcriptional point. Post-Transcriptional Gene legislation, moment Edition is equipped in six sections describing bioinformatics methods for learning post-transcriptional legislation, numerous expression profiling techniques, protein-RNA interplay and non-coding RNA research concepts, tools for profiling RNA changes, and different concepts comparable to replacement translation initiation or polyadenylation websites choice. Written for the Methods in Molecular Biology sequence, chapters comprise introductions to their respective themes, lists of the required fabrics and reagents, step by step, quite simply reproducible laboratory protocols, and pointers on troubleshooting and averting recognized pitfalls.
Authoritative and useful, Post-Transcriptional Gene rules, moment version is a flexible source to researchers learning post-transcriptional legislation, introducing the newest ideas and offering a complete consultant to their implementation.
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Additional info for Post-Transcriptional Gene Regulation
Kearns, and René Maehr Abstract CRISPR/Cas9-based regulation of gene expression provides the scientific community with a new highthroughput tool to dissect the role of genes in molecular processes and cellular functions. Single-guide RNAs allow for recruitment of a nuclease-dead Cas9 protein and transcriptional Cas9-effector fusion proteins to specific genomic loci, thereby modulating gene expression. We describe the application of a CRISPR-Cas9 effector system from Streptococcus pyogenes for transcriptional regulation in mammalian cells resulting in activation or repression of transcription.
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Post-Transcriptional Gene Regulation by Erik Dassi (eds.)