Prions: the new biology of proteins by Claudio Soto PDF

By Claudio Soto

ISBN-10: 0849314429

ISBN-13: 9780849314421

"Prions: the hot Biology of Proteins offers a well-organized evaluate of what's shortly identified approximately prion-related ailments. This accomplished paintings stories the medical signs, epidemiology, and neuropathology of the disorder. It makes a speciality of proof aiding the concept that TSEs end result from a completely novel ailment mechanism, concerning transmission by way of replication of the misfolding of a unmarried protein in the Read more...

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Additional resources for Prions: the new biology of proteins

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Struct. , 10, 725–730, 2003. *Legname, G. , Synthetic mammalian prions, Science, 305, 673–676, 2004. (Describes for the first time the generation of infectious prion protein in vitro. ) Lehmann, S. , Two mutant prion proteins expressed in cultured cells acquire biochemical properties reminiscent of the scrapie isoform, Proc. Natl. Acad. Sci. USA, 93, 5610–5614, 1996. *Lundmark, K. , Transmissibility of systemic amyloidosis by a prionlike mechanism, Proc. Natl. Acad. Sci. USA, 99, 6979–6984, 2002.

BSE and prions: uncertainties about the agent, Science, 279, 42–43, 1998. Chesebro, B. , Identification of scrapie prion protein-specific mRNA in scrapie-infected and uninfected brain, Nature, 315, 331–333, 1985. Chiesa, R. , Neurological illness in transgenic mice expressing a prion protein with an insertional mutation, Neuron, 21, 1339–1351, 1998. , Is the scrapie agent a virus? Nature, 262, 411–412, 1976. E. , Pathologic conformations of prion proteins, Annu. Rev. , 67, 793–819, 1998. , Prion diseases of humans and animals: their causes and molecular basis, Annu.

Sci. USA, 102, 646–650, 2005. , Trafficking, turnover and membrane topology of PrP, Br. Med. , 66, 71–85, 2003. * Highlight primary articles of outstanding importance and quality, including a short description of the findings. ** Highlights comprehensive review articles related to the topic of this chapter. , Thermodynamics of model prions and its implications for the problem of prion protein folding, J. Mol. , 286, 593–606, 1999. F. , Molecular classification of sporadic Creutzfeldt-Jakob disease, Brain, 126, 1333–1346, 2003.

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Prions: the new biology of proteins by Claudio Soto


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