By Martin Welschof (Editor), Jurgen Krauss (Editor)
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Additional resources for Recombinant Antibodies for Cancer Therapy: Methods and Protocols (Methods in Molecular Biology Vol 207)
Kipriyanov, S. , and Little, M. (1999) Di-, tri- and tetrameric single chain Fv antibody fragments against human CD19: effect of valency on cell binding. FEBS Lett. 453, 164–168. 108. Pack, P. and Pluckthun, A. (1992) Miniantibodies: use of amphipathic helices to produce functional, flexibly linked dimeric Fv fragments with high avidity in Escherichia coli. Biochemistry 31, 1579–1584. 109. , Williams, L. , Wong, J. , et al. (1996) Minibody: a novel engineered anti-carcinoembryonic antigen antibody fragment (single-chain Fv-CH3) which exhibits rapid, high-level targeting of xenografts.
138. Holt, L. , de Wildt, R. , and Tomlinson, I. M. (2000) The use of recombinant antibodies in proteomics. Curr. Opin. Biotechnol. 11, 445–449. 26 Kipriyanov Application of Recombinant Antibodies 27 2 Application of Recombinant Antibodies in Cancer Patients Jürgen Krauss, Michaela Arndt, and Michael Pfreundschuh 1. Introduction As a consequence of the invention of the hybridoma technology by Köhler and Milstein (1), many monoclonal antibodies (MAbs) have been evaluated in clinical trials since the early 1980s.
And Lerner, R. A. (1992) Semisynthetic combinatorial antibody libraries: a chemical solution to the diversity problem. Proc. Natl. Acad. Sci. USA 89, 4457–4461. , Hoogenboom, H. , Tomlinson, I. , and Winter, G. (1994) Antibody fragments from a ‘single pot’ phage display library as immunochemical reagents. EMBO J. 13, 692–698. Hoogenboom, H. R. and Chames, P. (2000) Natural and designer binding sites made by phage display technology. Immunol. Today 21, 371–378. 22 Kipriyanov 67. Xie, M. , and Gurney, A.
Recombinant Antibodies for Cancer Therapy: Methods and Protocols (Methods in Molecular Biology Vol 207) by Martin Welschof (Editor), Jurgen Krauss (Editor)