Signal Transducers and Activators of Transcription (STATs): - download pdf or read online

By James E. Darnell Jr. (auth.), Pravin B. Sehgal, David E. Levy, Toshio Hirano (eds.)

ISBN-10: 9048164214

ISBN-13: 9789048164219

ISBN-10: 9401730008

ISBN-13: 9789401730006

The yr 2003 marks the 10th anniversary of the 1st use of the acronym "Stat" (also written "STAT") within the medical literature for a relations of transcription components which speedily transduce cytokine-and progress issue­ elicited indications from the plasma membrane to the mobilephone nucleus thereby activating gene transcription (thus, . s. ignal Transducers and Activators of Transcription). From these beginnings, the sphere of STAT transcription elements, their similar regulatory molecules and their biology has grown exponentially in lots of assorted instructions. In attractiveness of the fast development and vast scope of the STAT transcription issue box this present day, and to have fun the 10th anniversary of using this time period within the medical literature, Kluwer educational Publishers B. V. asked us to collect a quantity on STAT transcription components that may function an outline of this burgeoning sector. therefore, we would have liked a quantity that may function a reference for what's recognized approximately STAT proteins and their biology, might describe the present kingdom of ongoing learn during this wide quarter, and could glance towards the longer term to aim to foretell the discoveries that lie forward. Our cost used to be to search out the superior specialists within the box and to coax them to in brief summarize their parts of expertise.

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Friedman, R. , Manly, S. , Kerr, I. M. and Stark, G. R. , Babiss, L. E. and Damell, J. , Jr. , Levy, D. , Jr. and Darnell, J. , Jr. (1987) Proc Natl Acad Sci USA 84, 6394-6398 Friedman, R. L. and Stark, G. R. (1985) Nature 314,637-639 Pellegrini, S. and Schindler, C. , Damell, J. , Stark, G. R. and Kerr, I. M. (1993) EMBOJ12, 4221-4228 Perkins, N. D. (2000) Trends Biochem Sci 25,434-440 Baeuerle, P. A. and Baltimore, D. (1996) Cell 87, 13-20 Brivanlou, A. H. and Darnell, J. , Jr. , Boggon, T. , Baird, C.

32 P. SAHARINEN AND O. SILVENNOINEN The activation loop (A-loop) region in protein tyrosine kinase domains contains tyrosine residues with a regulatory function (reviewed in 41). The A-loop of Jaks contains a conserved double tyrosine motif, which is phosphorylated in Jaks in response to cytokine stimulation (42). However, clear differences have been found in regulation of Jak kinases by the double tyrosine motif. Phosphorylation of the first tyrosine in the A-loop motif is critical for the catalytic activity of Jakl and Jak2, but not for Jak3 activity (43-45).

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Signal Transducers and Activators of Transcription (STATs): Activation and Biology by James E. Darnell Jr. (auth.), Pravin B. Sehgal, David E. Levy, Toshio Hirano (eds.)

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