By Vincent J. Cristofalo (auth.), Vincent J. Cristofalo Ph.D., M. Powell Lawton Ph.D. (eds.)
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Extra resources for Special Focus on the Biology of Aging
M. 1975. Variegated translocation mosaicism in human skin fibroblast cultures. Cytol Ce/I Genet, 25, 282-298. , Bryand, E. , Rabinovitch, P. , & Martin, G. M. 1980. Effects of chromosome constitution on growth and longevity of human skin fibroblast cultures. American Journal Medical Genetics, 7, 141-154. 40 W. T. , Incefy, G. , & Good, R. A. 1981. Circulating thymic hormone activity in patients and secondary immunodeficiency diseases. American Journal of Medicine, 71, 385394. Jones, K. , Smith, P.
0 No. 1F-M; father's age minus mother's age. , familial hypercholesterolemia) in which half the normal level of the gene product can lead to a disease. Several genetic considerations suggest progeria is most likely a sporadic dominant mutation. , first-cousin marriages) are expected in rare recessive diseases. High consanguinity is not seen in progeria, and none of the patients I have examined came from consanguineous 28 W. T. BROWN marriages. I estimate the frequency of progeria cases born to consanguineous marriages to be less than 3%.
L. ), Handbook 0/ the Biology 0/ Aging (p. 540). New York: Van Nostrand Reinhold. Medawar, P. B. (1952). An unsolved problem 0/ biology. London: H. K. Lewis. , Holliday, R. (1981). Increased error frequency of DNA polymerases from senescent human fibroblasts. Journal 0/ Molecular Biology, 146, 55. Oliver, C. , et al. (1985). Age-related alterations of enzymes may involve mixedfunction oxidation reactions. In R. C. Adelman, & E. E. ), Modification 0/ Proteins During Aging (p. 39). New York: Alan Liss.
Special Focus on the Biology of Aging by Vincent J. Cristofalo (auth.), Vincent J. Cristofalo Ph.D., M. Powell Lawton Ph.D. (eds.)