Download PDF by Ivan Bertoncello: Stem Cells in the Lung: Development, Repair and Regeneration

By Ivan Bertoncello

ISBN-10: 3319210815

ISBN-13: 9783319210810

ISBN-10: 3319210823

ISBN-13: 9783319210827

This e-book offers a accomplished evaluate of the present figuring out of the association of endogenous lung stem and progenitor mobilephone booths in the course of fetal lung improvement, postnatal lung progress and in maturity. Progressing level via degree, the chapters on fetal lung improvement emphasize the built-in position of epithelial, stromal, vascular and neural mobile components in construction a practical lung, whereas the next chapters on grownup lung regeneration describe the character and houses of grownup lung stem/progenitor cells dispensed alongside the proximal-distal axis of the airway tree. The chapters on rules of lung regeneration and service speak about how regenerative cells engage with their area of interest microenvironment and the way law of lung regeneration and service within the regular nation and following harm recapitulates ontogeny. And, finally, the chapters on mobile cures for lung ailment and bioengineering the lung specialise in promising rising remedies and ways in lung regenerative medication. The scope of this quantity of the Stem telephone Biology and Regenerative drugs sequence makes a speciality of exploring the subject of establishing and rebuilding the lung from a mobile instead of a molecular point of view. therefore, the part on mobile remedies doesn't comprise wide insurance of every of the various lung ailments, together with melanoma, which can be amenable to stem cell-based treatments, even if the ultimate bankruptcy does contain a few dialogue at the destiny customers and demanding situations. the entire individuals are engaged on the leading edge of the lung stem mobilephone box, making this booklet crucial analyzing for people with an curiosity within the box of lung stem phone biology and the aptitude function of mobile treatments and tissue bioengineering ways in lung regenerative medication, together with biomedical scientists, graduate scholars, post-graduate researchers and respiration clinicians.

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Additional info for Stem Cells in the Lung: Development, Repair and Regeneration

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J Biol Chem 281:8724–8731 52. D’Angio CT, Ryan RM (2014) Animal models of bronchopulmonary dysplasia. The preterm and term rabbit models. Am J Physiol Lung Cell Mol Physiol 307:L959–L969 53. Berger J, Bhandari V (2014) Animal models of bronchopulmonary dysplasia. The term mouse models. Am J Physiol Lung Cell Mol Physiol 307:L936–L947 54. O’Reilly M, Thebaud B (2014) Animal models of bronchopulmonary dysplasia. The term rat models. Am J Physiol Lung Cell Mol Physiol 307:L948–L958 55. Yoder BA, Coalson JJ (2014) Animal models of bronchopulmonary dysplasia.

The capacity of the primitive lung mesenchyme to differentiate into vascular endothelium was recently demonstrated in a new culture system and cells with the highest Flk-1 expression differentiated into endothelia more efficiently [7]. Studies in human fetal lung suggest that airways act as a template for pulmonary artery development, and that endothelial tubes form around the terminal buds of distal air spaces, suggesting an inductive influence of the epithelium [8]. Pereda et al. used immunolocalization and expression of CD31, CD34, FLT-1, KDR, and VEGF to show that at day 31 postfertilization (pf), a capillary plexus was already installed, and a few primitive erythroblasts were seen within the lumen of some blood vessels.

Gerber HP, Hillan KJ, Ryan AM, Kowalski J, Keller GA, Rangell L et al (1999) VEGF is required for growth and survival in neonatal mice. Development 126:1149–1159 19. Healy AM, Morgenthau L, Zhu X, Farber HW, Cardoso WV (2000) VEGF is deposited in the subepithelial matrix at the leading edge of branching airways and stimulates neovascularization in the murine embryonic lung. Dev Dyn 219:341–352 20. Gebb SA, Shannon JM (2000) Tissue interactions mediate early events in pulmonary vasculogenesis. Dev Dyn 217:159–169 21.

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Stem Cells in the Lung: Development, Repair and Regeneration by Ivan Bertoncello


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