By Mouldy, Ed. Sioud
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Additional info for Target Discovery and Validation Reviews and Protocols, Vol 2: Emerging Molecular Targets and Treatment Options (Methods in Molecular Biology Vol 361)
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Treatment of tumor cells with 5-AZA reduces the level of methylated lysine-9 in histone-3 and increases the level of methylated lysine4 in histone-3 in the promoter region of genes silenced by aberrant DNA methylation (51). As an example of cooperativity between chromatin modifications, it is interesting to note that Lys9 in histone-3 is acetylated in euchromatin (active state for gene transcription) but appears to be methylated in regions of gene-expression silencing (52). Methylated K4 and K79 and acetylated K9 and K14 of H3 are associated with transcriptionally active regions.
Target Discovery and Validation Reviews and Protocols, Vol 2: Emerging Molecular Targets and Treatment Options (Methods in Molecular Biology Vol 361) by Mouldy, Ed. Sioud