By Charles J. Dorman, G. Dougan, D. W. Holden, P. Williams, Harry Smith
Pathogenic micro organism have precise organic houses, which permit them to invade a bunch and reason ailment. The molecular bases of those organic homes are the determinants of pathogenicity, and the study ambitions are to acknowledge them, establish them chemically and relate their constitution to operate. such a lot of our current wisdom comes from stories with cultures in vitro. notwithstanding, there's a emerging curiosity in bacterial behaviour within the contaminated host and new tools were built for learning it. This ebook describes these tools and exhibits how they, and a up to date surge in traditional experiences, are laying off mild at the actions of bacterial pathogens in vivo. It discusses bacterial and host components that function in vivo to reason affliction, displaying how phenomena well-known in vitro relate to behavior in vivo and, if proof of relevance isn't on hand now, indicating the way it could be received.
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Additional resources for The activities of bacterial pathogens in vivo: based on contributions to a Royal Society discussion meeting, London, UK: meeting held on 20-21 October 1999
The topA gene, coding for the DNA relaxing enzyme topoisomerase I, was not induced. Reporter plasmid data showed that bacterial DNA became relaxed following uptake of S. typhimurium cells by the macrophage. These data indicate that DNA topology in S. typhimurium undergoes significant changes during adaptation to the intracellular environment. A model describing how this process may operate is discussed. K e y w o r d s : intracellular growth; DNA topology; gene expression; adaptation; Salmonella typhimurium 1.
Gen. Microbiol. 37, 265-292. Winson, M. K. (and 12 others) 1995 Multiple N-acyl-L-homoserinelactone signal molecules regulate production of virulence determinants and secondary metabolites in Pseudomonas aeruginosa. Proc. Natl Acad. Sci. USA 92, 9427-9431. , Parsons, N. , Cole, J. A. &; Smith, H. 1999 When lactate is used by gonococci growing in a medium containing glucose as occurs in vivo, its carbon is incorporated into lipid, LPS, GroEl and porin IB. In Abstracts of a Royal Society Meeting on the 'Activities of bacterial pathogens in vivo'.
1998). However, in infected macrophages DFI and IVET identified two and one gene, respectively, which were not controlled by PhoP/PhoQ (Valdivia & 20 H. Smith Falkow 1997a; Heithoff et al. 1999), thus indicating that this system is not the only one operating. With regard to virulence tests on mutants, a ToxR/ToxS-deficient mutant of V. cholerae produced less colonization and diarrhoea in volunteers than did the wild-type (Herrington et al. 1988), and PhoP/PhoQ-deficient mutants were avirulent for mice (Miller et al.
The activities of bacterial pathogens in vivo: based on contributions to a Royal Society discussion meeting, London, UK: meeting held on 20-21 October 1999 by Charles J. Dorman, G. Dougan, D. W. Holden, P. Williams, Harry Smith