By Gerald Litwack
General Description of quantity: quantity fifty one contains stories papers on cyclic AMP, kinases, polypeptide hormones, steroid hormone receptors, comparable genes, and individuals of the gene relations. General Description of sequence: less than the able and certified editorial management of Dr. Gerald Litwack, Vitamins and Hormones maintains to submit up to date artificial experiences of curiosity to endocrinologists and biochemists. Others drawn to the constitution and serve as of biologically lively molecules like hormones and supplementations will, as constantly, flip to this sequence for entire studies through prime members to this and similar disciplines. First released in 1943, Vitamins and Hormones is the longest-running serial released by means of educational Press. within the early days of the serial, the topics of supplementations and hormones have been really unique. Now, new discoveries have proved that a number of of the supplements functionality as hormones and lots of of the elements inferred through the identify of the Serial functionality in sign transduction strategies. consequently, the editor-in-chief has increased the scope of the serial to mirror this more moderen realizing of function-structure relationships in mobile verbal exchange. The newly transformed editorial board now displays services within the box of hormone motion, nutrition motion, X-ray crystal constitution, body structure and enzyme mechanisms. Vitamins and Hormones keeps to post up to date artificial stories of curiosity to endocrinologists and biochemists. Others will more and more flip to this sequence for entire experiences via prime researchers during this and comparable disciplines.
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Extra resources for Vitamins and Hormones, Vol. 51
The formation of specific dimers of transcription factors within the nucleus predictably would depend on the concentrations of the proteins relative to one another, which, in turn, depend on their relative rates of formation and degradation. In many instances it has been established that the expression of genes encoding DNA-binding transcription factors is regulated by either autopositive or autonegative feedback control mechanisms, as has been found for CREB and for the ICER isoform of CREM. Important directions of investigation will be to decipher the mechanisms that control the complex autoregulatory networks of gene transcription, for example, elucidation of the feedback control mechanism by which targeted disruption of the CREB gene in mice leads to a 10-fold compensatory increase in the expression of the CREM gene.
9B). The discovery of CBP has revealed interesting implications for the alterations in gene transcription elicited by certain viral proteins mediated via CRE-like elements. , 1994). , 1992). , 1994) that interactions between CREB and p300, as well as between viral E1A (or its putative cellular counterpart) and CBP may occur in cells. , 19941, which activates gene transcription in response to mitogenic stimuli. Accordingly, these interactions among CREB, CBP, and p300 may provide a molecular substrate for the observed effects elicited by cAMP on cell proliferation and differentiation.
RNA-binding proteins and DNA binding domains of transcription factors have been described (reviewed in Rabbits, 1994). It is notable that, as yet, no subjects with oncogenic isoforms of CREB or CREM have been uncovered, particularly since the multiply spliced exons and large introns in these genes would theoretically predispose the subject to miss-splice mutations or recombinatorial translocations. Interestingly, several other bZIP proteins related to CREB and CREM, such as c-Jun, c-Fos, and c-Myc,were originally discovered as their oncogenic variants, in the guise of “tumor viruses” in chickens and rabbits.
Vitamins and Hormones, Vol. 51 by Gerald Litwack